ID:SYCP1_HUMAN DESCRIPTION: RecName: Full=Synaptonemal complex protein 1; Short=SCP-1; AltName: Full=Cancer/testis antigen 8; Short=CT8; FUNCTION: Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. SUBUNIT: Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Chromosome (By similarity). Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C- terminus extends well into the lateral domain of the synaptonemal complex (By similarity). TISSUE SPECIFICITY: Testis. DOMAIN: Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity (By similarity).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05483 - Synaptonemal complex protein 1 (SCP-1)
ModBase Predicted Comparative 3D Structure on Q15431
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.