Human Gene NGF (ENST00000369512.3) from GENCODE V44
Description: Homo sapiens nerve growth factor (NGF), mRNA. (from RefSeq NM_002506) RefSeq Summary (NM_002506): This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000369512.3 Gencode Gene: ENSG00000134259.6 Transcript (Including UTRs) Position: hg38 chr1:115,285,917-115,338,249 Size: 52,333 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr1:115,286,070-115,286,795 Size: 726 Coding Exon Count: 1
ID:NGF_HUMAN DESCRIPTION: RecName: Full=Beta-nerve growth factor; Short=Beta-NGF; Flags: Precursor; FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Secreted. DISEASE: Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. SIMILARITY: Belongs to the NGF-beta family. SEQUENCE CAUTION: Sequence=AAH32517.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=Wikipedia; Note=Nerve growth factor entry; URL="http://en.wikipedia.org/wiki/Nerve_growth_factor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01138
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000186 activation of MAPKK activity GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007267 cell-cell signaling GO:0008285 negative regulation of cell proliferation GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0010466 negative regulation of peptidase activity GO:0010469 regulation of receptor activity GO:0010628 positive regulation of gene expression GO:0032455 nerve growth factor processing GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043388 positive regulation of DNA binding GO:0043524 negative regulation of neuron apoptotic process GO:0045664 regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation GO:0046579 positive regulation of Ras protein signal transduction GO:0048011 neurotrophin TRK receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048812 neuron projection morphogenesis GO:0050772 positive regulation of axonogenesis GO:0051402 neuron apoptotic process