Human Gene ITGA10 (ENST00000369304.8) from GENCODE V44
Description: Homo sapiens integrin subunit alpha 10 (ITGA10), transcript variant 1, mRNA. (from RefSeq NM_003637) RefSeq Summary (NM_003637): Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. Gencode Transcript: ENST00000369304.8 Gencode Gene: ENSG00000143127.13 Transcript (Including UTRs) Position: hg38 chr1:145,891,208-145,910,050 Size: 18,843 Total Exon Count: 30 Strand: - Coding Region Position: hg38 chr1:145,892,798-145,910,014 Size: 17,217 Coding Exon Count: 30
ID:ITA10_HUMAN DESCRIPTION: RecName: Full=Integrin alpha-10; Flags: Precursor; FUNCTION: Integrin alpha-10/beta-1 is a receptor for collagen. SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed with highest expression in muscle and heart. Found in articular cartilage. DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. SIMILARITY: Belongs to the integrin alpha chain family. SIMILARITY: Contains 7 FG-GAP repeats. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08441 - Integrin alpha PF00092 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on O75578
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
