Human Gene NBPF14 (uc001ern.1) Description and Page Index
  Description: hypothetical protein LOC25832
RefSeq Summary (NM_001039703): This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Transcript (Including UTRs)
   Position: hg18 chr1:146,638,416-146,693,472 Size: 55,057 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg18 chr1:146,638,418-146,685,340 Size: 46,923 Coding Exon Count: 18 

Page IndexSequence and LinksCTDMicroarray ExpressionRNA StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:146,638,416-146,693,472)mRNA (may differ from genome)Protein (676 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCMGIOMIMPubMedStanford SOURCE
TreefamUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -224.74673-0.334 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK294944 - Homo sapiens cDNA FLJ60520 complete cds, weakly similar to Homo sapiens phosphodiesterase 4D interacting protein, transcript variant 1, mRNA.
AF379636 - Homo sapiens AG11 mRNA, partial cds.
AL050141 - Homo sapiens mRNA; cDNA DKFZp586O031 (from clone DKFZp586O031).
DQ786323 - Homo sapiens clone HLS_IMAGE_843276 mRNA sequence.
AK295639 - Homo sapiens cDNA FLJ61634 complete cds.
AY894565 - Homo sapiens clone IIIa12 NBPF9 isoform 1 mRNA, complete cds, alternatively spliced.
BC148331 - Synthetic construct Homo sapiens clone IMAGE:100015301, MGC:182975 neuroblastoma breakpoint family, member 10 (NBPF10) mRNA, encodes complete protein.
AB527190 - Synthetic construct DNA, clone: pF1KA1693, Homo sapiens NBPF9 gene for neuroblastoma breakpoint family, member 9, without stop codon, in Flexi system.
AF379636 - Homo sapiens AG11 mRNA, partial cds.
AF379633 - Homo sapiens AG6 mRNA, partial cds.
DQ786323 - Homo sapiens clone HLS_IMAGE_843276 mRNA sequence.
AF379636 - Homo sapiens AG11 mRNA, partial cds.
AF379633 - Homo sapiens AG6 mRNA, partial cds.
AF379632 - Homo sapiens AG4 mRNA, partial cds.
AL050141 - Homo sapiens mRNA; cDNA DKFZp586O031 (from clone DKFZp586O031).
DQ786323 - Homo sapiens clone HLS_IMAGE_843276 mRNA sequence.
AF161426 - Homo sapiens HSPC308 mRNA, partial cds.
DQ786323 - Homo sapiens clone HLS_IMAGE_843276 mRNA sequence.
AF161426 - Homo sapiens HSPC308 mRNA, partial cds.
AL050141 - Homo sapiens mRNA; cDNA DKFZp586O031 (from clone DKFZp586O031).
AF419616 - Homo sapiens clone DKFZp564A057 AG02 mRNA, partial cds.
AK292666 - Homo sapiens cDNA FLJ78770 complete cds.
AF161426 - Homo sapiens HSPC308 mRNA, partial cds.
AL050141 - Homo sapiens mRNA; cDNA DKFZp586O031 (from clone DKFZp586O031).
AF379633 - Homo sapiens AG6 mRNA, partial cds.
AF379632 - Homo sapiens AG4 mRNA, partial cds.
AF379632 - Homo sapiens AG4 mRNA, partial cds.
AF379636 - Homo sapiens AG11 mRNA, partial cds.
AF380582 - Homo sapiens AG8 mRNA, partial cds.
DQ786323 - Homo sapiens clone HLS_IMAGE_843276 mRNA sequence.
AF380582 - Homo sapiens AG8 mRNA, partial cds.
AF379620 - Homo sapiens AB14 precursor RNA, partial cds.
AF420437 - Homo sapiens AB14 precursor RNA, partial cds.
AF379620 - Homo sapiens AB14 precursor RNA, partial cds.
AF379619 - Homo sapiens AB13 precursor RNA, partial cds.
AF379619 - Homo sapiens AB13 precursor RNA, partial cds.
AF420437 - Homo sapiens AB14 precursor RNA, partial cds.
JD372775 - Sequence 353799 from Patent EP1572962.
JD040586 - Sequence 21610 from Patent EP1572962.
JD021612 - Sequence 2636 from Patent EP1572962.
JD032812 - Sequence 13836 from Patent EP1572962.
JD148192 - Sequence 129216 from Patent EP1572962.
JD108450 - Sequence 89474 from Patent EP1572962.
JD077036 - Sequence 58060 from Patent EP1572962.
JD040586 - Sequence 21610 from Patent EP1572962.
BC021111 - Homo sapiens neuroblastoma breakpoint family, member 10, mRNA (cDNA clone IMAGE:5090304).
AK000726 - Homo sapiens cDNA FLJ20719 fis, clone HEP17004.
BC063799 - Homo sapiens neuroblastoma breakpoint family, member 10, mRNA (cDNA clone IMAGE:6526820), partial cds.
AF379632 - Homo sapiens AG4 mRNA, partial cds.
AF380581 - Homo sapiens AG3 mRNA, partial cds.
AF380582 - Homo sapiens AG8 mRNA, partial cds.
DQ786323 - Homo sapiens clone HLS_IMAGE_843276 mRNA sequence.
AF379620 - Homo sapiens AB14 precursor RNA, partial cds.
AF420437 - Homo sapiens AB14 precursor RNA, partial cds.
AF379619 - Homo sapiens AB13 precursor RNA, partial cds.
AF379619 - Homo sapiens AB13 precursor RNA, partial cds.
AF379620 - Homo sapiens AB14 precursor RNA, partial cds.
AF420437 - Homo sapiens AB14 precursor RNA, partial cds.
JD040586 - Sequence 21610 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MSG8, A8MSG8_HUMAN, AF379633, NBPF20, NM_015383, NP_056198
UCSC ID: uc001ern.1
RefSeq Accession: NM_001039703

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AF379633.1
exon count: 22CDS single in 3' UTR: no RNA size: 2579
ORF size: 2028CDS single in intron: no Alignment % ID: 99.57
txCdsPredict score: 1935.00frame shift in genome: no % Coverage: 99.96
has start codon: yes stop codon in genome: no # of Alignments: 16
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.