ID:TP8L2_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor alpha-induced protein 8-like protein 2; Short=TIPE2; Short=TNF alpha-induced protein 8-like protein 2; Short=TNFAIP8-like protein 2; AltName: Full=Inflammation factor protein 20; FUNCTION: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity). SUBUNIT: May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8. DOMAIN: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding. SIMILARITY: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. SEQUENCE CAUTION: Sequence=AAG44785.1; Type=Frameshift; Positions=117;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P589
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0042981 regulation of apoptotic process GO:0045087 innate immune response GO:0050728 negative regulation of inflammatory response GO:0050868 negative regulation of T cell activation