Human Gene VPS72 (ENST00000368892.9) from GENCODE V44
Description: Homo sapiens vacuolar protein sorting 72 homolog (VPS72), transcript variant 2, mRNA. (from RefSeq NM_005997) RefSeq Summary (NM_005997): The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]. Gencode Transcript: ENST00000368892.9 Gencode Gene: ENSG00000163159.15 Transcript (Including UTRs) Position: hg38 chr1:151,176,304-151,190,197 Size: 13,894 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr1:151,176,644-151,190,121 Size: 13,478 Coding Exon Count: 6
ID:VPS72_HUMAN DESCRIPTION: RecName: Full=Vacuolar protein sorting-associated protein 72 homolog; AltName: Full=Protein YL-1; AltName: Full=Transcription factor-like 1; FUNCTION: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling. SUBUNIT: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ. INTERACTION: Q9Y265:RUVBL1; NbExp=6; IntAct=EBI-399189, EBI-353675; SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the VPS72/YL1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05764 - YL1 nuclear protein PF08265 - YL1 nuclear protein C-terminal domain
ModBase Predicted Comparative 3D Structure on Q15906
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
