Human Gene RORC (ENST00000318247.7) Description and Page Index
Description: Homo sapiens RAR related orphan receptor C (RORC), transcript variant 1, mRNA. (from RefSeq NM_005060) RefSeq Summary (NM_005060): The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000318247.7 Gencode Gene: ENSG00000143365.19 Transcript (Including UTRs) Position: hg38 chr1:151,806,071-151,831,802 Size: 25,732 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr1:151,807,472-151,831,764 Size: 24,293 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00104 - Ligand-binding domain of nuclear hormone receptor PF00105 - Zinc finger, C4 type (two domains)
ModBase Predicted Comparative 3D Structure on Q6I9R9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding