Human Gene THBS3 (ENST00000368378.7) from GENCODE V44
Description: Homo sapiens thrombospondin 3 (THBS3), transcript variant 1, mRNA. (from RefSeq NM_007112) RefSeq Summary (NM_007112): The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]. Gencode Transcript: ENST00000368378.7 Gencode Gene: ENSG00000169231.13 Transcript (Including UTRs) Position: hg38 chr1:155,195,588-155,207,897 Size: 12,310 Total Exon Count: 23 Strand: - Coding Region Position: hg38 chr1:155,195,841-155,207,876 Size: 12,036 Coding Exon Count: 23
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11598 - Cartilage oligomeric matrix protein PF07645 - Calcium-binding EGF domain PF02412 - Thrombospondin type 3 repeat PF05735 - Thrombospondin C-terminal region
ModBase Predicted Comparative 3D Structure on P49746
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.