Human Gene NES (ENST00000368223.4) from GENCODE V44
Description: Homo sapiens nestin (NES), mRNA. (from RefSeq NM_006617) RefSeq Summary (NM_006617): This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000368223.4 Gencode Gene: ENSG00000132688.11 Transcript (Including UTRs) Position: hg38 chr1:156,668,763-156,677,407 Size: 8,645 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr1:156,669,322-156,677,264 Size: 7,943 Coding Exon Count: 4
ID:NEST_HUMAN DESCRIPTION: RecName: Full=Nestin; FUNCTION: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). SUBUNIT: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity). TISSUE SPECIFICITY: CNS stem cells. DEVELOPMENTAL STAGE: Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments. PTM: Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity). SIMILARITY: Belongs to the intermediate filament family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00038 - Intermediate filament protein
ModBase Predicted Comparative 3D Structure on P48681
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007417 central nervous system development GO:0007420 brain development GO:0030844 positive regulation of intermediate filament depolymerization GO:0031076 embryonic camera-type eye development GO:0032091 negative regulation of protein binding GO:0043086 negative regulation of catalytic activity GO:0072089 stem cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation
US Server
