Human Gene DEDD (ENST00000458050.6) from GENCODE V44
Description: Homo sapiens death effector domain containing (DEDD), transcript variant 4, mRNA. (from RefSeq NM_001039712) RefSeq Summary (NM_001039712): This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000458050.6 Gencode Gene: ENSG00000158796.17 Transcript (Including UTRs) Position: hg38 chr1:161,120,977-161,132,466 Size: 11,490 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr1:161,122,147-161,124,462 Size: 2,316 Coding Exon Count: 4
ID:DEDD_HUMAN DESCRIPTION: RecName: Full=Death effector domain-containing protein; AltName: Full=DEDPro1; AltName: Full=Death effector domain-containing testicular molecule; AltName: Full=FLDED-1; FUNCTION: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). SUBUNIT: Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2. INTERACTION: Q06481:APLP2; NbExp=3; IntAct=EBI-1043164, EBI-79306; SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus (By similarity). Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. TISSUE SPECIFICITY: Widely expressed with highest levels in testis. PTM: Exists predominantly in a mono- or diubiquitinated form. SIMILARITY: Contains 1 DED (death effector) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75618
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0007283 spermatogenesis GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0042981 regulation of apoptotic process
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
