Human Gene NR1I3 (ENST00000367984.8) from GENCODE V44
Description: Homo sapiens nuclear receptor subfamily 1 group I member 3 (NR1I3), transcript variant 5, mRNA. (from RefSeq NM_001077471) RefSeq Summary (NM_001077471): This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]. Gencode Transcript: ENST00000367984.8 Gencode Gene: ENSG00000143257.12 Transcript (Including UTRs) Position: hg38 chr1:161,229,772-161,238,111 Size: 8,340 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr1:161,229,797-161,236,565 Size: 6,769 Coding Exon Count: 7
ID:NR1I3_HUMAN DESCRIPTION: RecName: Full=Nuclear receptor subfamily 1 group I member 3; AltName: Full=Constitutive activator of retinoid response; Short=Constitutive active response; AltName: Full=Constitutive androstane receptor; Short=CAR; AltName: Full=Orphan nuclear receptor MB67; FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. SUBUNIT: Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7 (By similarity). TISSUE SPECIFICITY: Predominantly expressed in liver. INDUCTION: By dexamethasone. DOMAIN: Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains. PTM: Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14994
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HQ447449 - Synthetic construct Homo sapiens clone IMAGE:100070777; CCSB013990_01 nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene, encodes complete protein. KJ898127 - Synthetic construct Homo sapiens clone ccsbBroadEn_07521 NR1I3 gene, encodes complete protein. KR711359 - Synthetic construct Homo sapiens clone CCSBHm_00023120 NR1I3 (NR1I3) mRNA, encodes complete protein. KR711360 - Synthetic construct Homo sapiens clone CCSBHm_00023121 NR1I3 (NR1I3) mRNA, encodes complete protein. Z30425 - H.sapiens mRNA for orphan nuclear hormone receptor. BC069626 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:97209 IMAGE:7262456), complete cds. BC069651 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:97144 IMAGE:7262385), complete cds. AY572806 - Homo sapiens constitutive androstane receptor SV1 (NR1I3) mRNA, partial cds, alternatively spliced. AY572807 - Homo sapiens constitutive androstane receptor SV2 (NR1I3) mRNA, complete cds, alternatively spliced. AY572808 - Homo sapiens constitutive androstane receptor SV3 (NR1I3) mRNA, complete cds, alternatively spliced. AY572809 - Homo sapiens constitutive androstane receptor SV4 (NR1I3) mRNA, complete cds, alternatively spliced. AY572810 - Homo sapiens constitutive androstane receptor SV5 (NR1I3) mRNA, complete cds, alternatively spliced. AY572811 - Homo sapiens constitutive androstane receptor SV6 (NR1I3) mRNA, complete cds, alternatively spliced. AY572812 - Homo sapiens constitutive androstane receptor SV7 (NR1I3) mRNA, partial cds, alternatively spliced. AY572813 - Homo sapiens constitutive androstane receptor SV8 (NR1I3) mRNA, partial cds, alternatively spliced. AY572814 - Homo sapiens constitutive androstane receptor SV9 (NR1I3) mRNA, complete cds, alternatively spliced. AY572815 - Homo sapiens constitutive androstane receptor SV10 (NR1I3) mRNA, complete cds, alternatively spliced. AY572816 - Homo sapiens constitutive androstane receptor SV11 (NR1I3) mRNA, partial cds, alternatively spliced. AY572817 - Homo sapiens constitutive androstane receptor SV12 (NR1I3) mRNA, partial cds, alternatively spliced. AY572818 - Homo sapiens constitutive androstane receptor SV13 (NR1I3) mRNA, partial cds, alternatively spliced. AY572819 - Homo sapiens constitutive androstane receptor SV14 (NR1I3) mRNA, partial cds, alternatively spliced. AY572820 - Homo sapiens constitutive androstane receptor SV15 (NR1I3) mRNA, partial cds, alternatively spliced. AY572821 - Homo sapiens constitutive androstane receptor SV16 (NR1I3) mRNA, partial cds, alternatively spliced. AY572822 - Homo sapiens constitutive androstane receptor SV17 (NR1I3) mRNA, complete cds, alternatively spliced. AY572823 - Homo sapiens constitutive androstane receptor SV18 (NR1I3) mRNA, complete cds, alternatively spliced. AY572824 - Homo sapiens constitutive androstane receptor SV19 (NR1I3) mRNA, complete cds, alternatively spliced. AY572825 - Homo sapiens constitutive androstane receptor SV20 (NR1I3) mRNA, complete cds, alternatively spliced. AY572826 - Homo sapiens constitutive androstane receptor SV21 (NR1I3) mRNA, complete cds, alternatively spliced. AY572827 - Homo sapiens constitutive androstane receptor SV22 (NR1I3) mRNA, complete cds, alternatively spliced. BC121120 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:150433 IMAGE:40120664), complete cds. BC121121 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:150434 IMAGE:40120665), complete cds. JD205246 - Sequence 186270 from Patent EP1572962. JD140847 - Sequence 121871 from Patent EP1572962. AB307702 - Homo sapiens NR1I3 mRNA for constitutive androstane receptor, complete cds. DQ022681 - Homo sapiens nuclear receptor subfamily 1, group I, member 3 mRNA, complete cds, alternatively spliced. HQ692838 - Homo sapiens constitutive androstane nuclear receptor variant 2 (NR1i3) mRNA, complete cds. HQ692839 - Homo sapiens constitutive androstane nuclear receptor variant 3 (NR1i3) mRNA, complete cds. HQ692840 - Homo sapiens constitutive androstane nuclear receptor variant 4 (NR1i3) mRNA, complete cds. HQ692841 - Homo sapiens constitutive androstane nuclear receptor variant 5 (NR1i3) mRNA, complete cds. HQ709178 - Homo sapiens constitutive androstane nuclear receptor (NR1I3) mRNA, complete cds. CU686946 - Synthetic construct Homo sapiens gateway clone IMAGE:100022636 5' read NR1I3 mRNA. AK303757 - Homo sapiens cDNA FLJ50348 complete cds, highly similar to Orphan nuclear receptor NR1I3. AK310773 - Homo sapiens cDNA, FLJ17815. AK316208 - Homo sapiens cDNA, FLJ79107 complete cds, highly similar to Orphan nuclear receptor NR1I3. AK303796 - Homo sapiens cDNA FLJ56764 complete cds, highly similar to Orphan nuclear receptor NR1I3. BC030972 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone IMAGE:4556554), with apparent retained intron.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity h_AcetaminophenPathway - Mechanism of Acetaminophen Activity and Toxicity
Reactome (by CSHL, EBI, and GO)
Protein Q14994 (Reactome details) participates in the following event(s):