Human Gene RC3H1 (ENST00000258349.8) from GENCODE V44
Description: Homo sapiens ring finger and CCCH-type domains 1 (RC3H1), transcript variant 1, mRNA. (from RefSeq NM_001300850) RefSeq Summary (NM_172071): This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000258349.8 Gencode Gene: ENSG00000135870.12 Transcript (Including UTRs) Position: hg38 chr1:173,931,214-173,993,064 Size: 61,851 Total Exon Count: 19 Strand: - Coding Region Position: hg38 chr1:173,938,721-173,992,985 Size: 54,265 Coding Exon Count: 19
ID:RC3H1_HUMAN DESCRIPTION: RecName: Full=Roquin; AltName: Full=RING finger and C3H zinc finger protein 1; AltName: Full=RING finger protein 198; FUNCTION: Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Localizes to cytosolic RNA granules, which are sites for regulating mRNA translation and decay, suggesting that it may bind RNA (By similarity). TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver. SIMILARITY: Contains 1 C3H1-type zinc finger. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAC04186.1; Type=Erroneous initiation; Sequence=CAH70709.1; Type=Erroneous initiation; Sequence=CAH70710.1; Type=Erroneous initiation; Sequence=CAI19417.1; Type=Erroneous initiation; Sequence=CAI19419.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)
ModBase Predicted Comparative 3D Structure on Q5TC82
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000956 nuclear-transcribed mRNA catabolic process GO:0001782 B cell homeostasis GO:0002634 regulation of germinal center formation GO:0002635 negative regulation of germinal center formation GO:0010468 regulation of gene expression GO:0010608 posttranscriptional regulation of gene expression GO:0030889 negative regulation of B cell proliferation GO:0033962 cytoplasmic mRNA processing body assembly GO:0042098 T cell proliferation GO:0042129 regulation of T cell proliferation GO:0043029 T cell homeostasis GO:0043488 regulation of mRNA stability GO:0045623 negative regulation of T-helper cell differentiation GO:0046007 negative regulation of activated T cell proliferation GO:0048535 lymph node development GO:0048536 spleen development GO:0050852 T cell receptor signaling pathway GO:0050856 regulation of T cell receptor signaling pathway GO:0050863 regulation of T cell activation GO:0061014 positive regulation of mRNA catabolic process GO:0061158 3'-UTR-mediated mRNA destabilization GO:0061470 T follicular helper cell differentiation GO:0071347 cellular response to interleukin-1 GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:2000320 negative regulation of T-helper 17 cell differentiation GO:2000628 regulation of miRNA metabolic process
US Server
