Human Gene LHX9 (ENST00000367390.7) from GENCODE V44
Description: Homo sapiens LIM homeobox 9 (LHX9), transcript variant 2, mRNA. (from RefSeq NM_001014434) RefSeq Summary (NM_020204): This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000367390.7 Gencode Gene: ENSG00000143355.16 Transcript (Including UTRs) Position: hg38 chr1:197,912,505-197,935,478 Size: 22,974 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr1:197,912,532-197,929,259 Size: 16,728 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQ69
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0008283 cell proliferation GO:0008584 male gonad development GO:0008585 female gonad development GO:0035262 gonad morphogenesis GO:0045892 negative regulation of transcription, DNA-templated GO:0097380 dorsal spinal cord interneuron anterior axon guidance