Human Gene ATP2B4 (ENST00000357681.10) from GENCODE V44
Description: Homo sapiens ATPase plasma membrane Ca2+ transporting 4 (ATP2B4), transcript variant 2, mRNA. (from RefSeq NM_001684) RefSeq Summary (NM_001684): The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000357681.10 Gencode Gene: ENSG00000058668.16 Transcript (Including UTRs) Position: hg38 chr1:203,626,832-203,744,081 Size: 117,250 Total Exon Count: 21 Strand: + Coding Region Position: hg38 chr1:203,683,206-203,739,854 Size: 56,649 Coding Exon Count: 20
ID:AT2B4_HUMAN DESCRIPTION: RecName: Full=Plasma membrane calcium-transporting ATPase 4; Short=PMCA4; EC=3.6.3.8; AltName: Full=Matrix-remodeling-associated protein 1; AltName: Full=Plasma membrane calcium ATPase isoform 4; AltName: Full=Plasma membrane calcium pump isoform 4; FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. CATALYTIC ACTIVITY: ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). INTERACTION: Q63622:Dlg2 (xeno); NbExp=2; IntAct=EBI-1174437, EBI-396947; Q62936:Dlg3 (xeno); NbExp=2; IntAct=EBI-1174437, EBI-349596; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P23634
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003407 neural retina development GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006811 ion transport GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0007283 spermatogenesis GO:0010751 negative regulation of nitric oxide mediated signal transduction GO:0021766 hippocampus development GO:0030317 flagellated sperm motility GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0034220 ion transmembrane transport GO:0045019 negative regulation of nitric oxide biosynthetic process GO:0051001 negative regulation of nitric-oxide synthase activity GO:0051599 response to hydrostatic pressure GO:0070588 calcium ion transmembrane transport GO:0070885 negative regulation of calcineurin-NFAT signaling cascade GO:0071872 cellular response to epinephrine stimulus GO:0097553 calcium ion transmembrane import into cytosol GO:0098703 calcium ion import across plasma membrane GO:0098736 negative regulation of the force of heart contraction GO:0099132 ATP hydrolysis coupled cation transmembrane transport GO:1900082 negative regulation of arginine catabolic process GO:1901660 calcium ion export GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation GO:1902305 regulation of sodium ion transmembrane transport GO:1902806 regulation of cell cycle G1/S phase transition GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress GO:1903249 negative regulation of citrulline biosynthetic process GO:1903779 regulation of cardiac conduction GO:2000481 positive regulation of cAMP-dependent protein kinase activity
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