Human Gene CD34 (ENST00000356522.4) from GENCODE V44
Description: Homo sapiens CD34 molecule (CD34), transcript variant 2, mRNA. (from RefSeq NM_001773)
RefSeq Summary (NM_001773): The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000356522.4
Gencode Gene: ENSG00000174059.17
Transcript (Including UTRs)
Position: hg38 chr1:207,886,539-207,911,402 Size: 24,864 Total Exon Count: 8 Strand: -
Coding Region
Position: hg38 chr1:207,888,104-207,911,080 Size: 22,977 Coding Exon Count: 8
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: CD34_HUMAN
DESCRIPTION: RecName: Full=Hematopoietic progenitor cell antigen CD34; AltName: CD_antigen=CD34; Flags: Precursor;
FUNCTION: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.DEVELOPMENTAL STAGE: On early hematopoietic progenitor cells.PTM: Highly glycosylated.PTM: Phosphorylated on serine residues by PKC.SIMILARITY: Belongs to the CD34 family.SEQUENCE CAUTION: Sequence=AAA03181.1; Type=Erroneous initiation;WEB RESOURCE: Name=Wikipedia; Note=CD34 entry; URL="http://en.wikipedia.org/wiki/CD34";
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: CD34
Diseases sorted by gene-association score: dermatofibrosarcoma protuberans (10), neurofibroma (6), gastrointestinal stromal tumor (6), spindle cell lipoma (6), fibroma (5), acute leukemia (5), middle ear squamous cell carcinoma (5), hypercalcemic type ovarian small cell carcinoma (5), benign fibrous mesothelioma (4), pacinian tumor (4), gastric liposarcoma (4), vulvar proximal-type epithelioid sarcoma (4), central epithelioid sarcoma (4), leiomyoma (4), myelodysplastic syndrome (4), atypical neurofibroma (4), hemangioma (4), liposarcoma (4), aplastic anemia (4), malignant peripheral nerve sheath tumor (3), leukemia, chronic myeloid, somatic (3), testicular fibroma (3), breast myofibroblastoma (3), ovarian angiosarcoma (3), ovary sarcoma (3), hepatocellular carcinoma (3), epithelioid neurofibroma (3), lung leiomyosarcoma (3), pineal region choriocarcinoma (3), prostate stromal sarcoma (3), mechanical ectropion (3), acquired immunodeficiency syndrome (3), gallbladder leiomyoma (3), kaposiform hemangioendothelioma (3), idiopathic interstitial pneumonia (3), cellular neurofibroma (3), kidney hemangiopericytoma (2), hobnail hemangioma (2), chronic neutrophilic leukemia (2), leukemia, acute lymphoblastic (2), glomangiomyoma (2), connective tissue cancer (2), t-cell adult acute lymphocytic leukemia (2), intravascular fasciitis (2), multiple myeloma (2), mesenchymal cell neoplasm (2), malignant pineal area germ cell neoplasm (2), integumentary system benign neoplasm (2), pediatric angiosarcoma (2), pleomorphic lipoma (2), adult mesoblastic nephroma (2), retina lymphoma (2), vulvar dystrophy (2), ovarian solid teratoma (2), tibial adamantinoma (2), liver leiomyoma (2), synovium cancer (2), nervous system benign neoplasm (2), small intestinal sarcoma (2), thyroid angiosarcoma (2), organ system benign neoplasm (2), small intestine leiomyosarcoma (2), cell type benign neoplasm (2), trigonitis (2), combined t cell and b cell immunodeficiency (2), exophthalmos (2), plexiform schwannoma (2), leukocyte disease (2), adult xanthogranuloma (2), deep leiomyoma (2), conventional angiosarcoma (2), melanotic neurilemmoma (2), atypical lipomatous tumor (2), breast angiosarcoma (2), angiomyoma (2), muscle cancer (2), breast benign neoplasm (2), thoracic benign neoplasm (2), spindle cell liposarcoma (1), neurogenic arthropathy (1), meningioma, familial (1), peripheral nervous system neoplasm (1), gallbladder sarcoma (1), lung meningioma (1), glomeruloid hemangioma (1), spleen angiosarcoma (1), breast leiomyosarcoma (1), lymphoma, non-hodgkin (1), bone epithelioid hemangioma (1), immune system disease (1), extracutaneous mastocytoma (1), vulvar sarcoma (1), spleen cancer (1), leukemia, acute myeloid (1), cell type cancer (1), liver inflammatory pseudotumor (1), psammomatous meningioma (1), erythema elevatum diutinum (1), conventional fibrosarcoma (1), sternum cancer (1), orbital granuloma (1), myelofibrosis with myeloid metaplasia, somatic (1), lymphangiosarcoma (1), thyroid sarcoma (1), meninges sarcoma (1), venous hemangioma (1), myocardial infarction (1), meninges hemangiopericytoma (1), paraphimosis (1), cardiovascular organ benign neoplasm (1), benign perivascular tumor (1), ischemic fasciitis (1), gastrointestinal system cancer (1), cellular schwannoma (1), interstitial emphysema (1), invasive malignant thymoma (1), extraosseous osteosarcoma (1), infiltrating lipoma (1), hemangioma of liver (1), hemangioma of intra-abdominal structure (1), diffuse cutaneous mastocytosis (1), prostate leiomyosarcoma (1), nervous system cancer (1), mixed liposarcoma (1), internal hemorrhoid (1), sarcomatoid squamous cell skin carcinoma (1), sclerosing liposarcoma (1), diffuse meningeal melanocytosis (1), eccrine adenocarcinoma (1), chorioangioma (1), glomangioma (1), deep angioma (1), chronic monocytic leukemia (1), liver angiosarcoma (1), nephrogenic adenofibroma (1), aleukemic leukemia cutis (1), intraneural perineurioma (1), proliferative fasciitis (1), skin sarcoma (1), clear cell ependymoma (1), congenital epulis (1), intramuscular hemangioma (1), pediatric lymphoma (1), spindle cell synovial sarcoma (1), reticulohistiocytic granuloma (1)
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR008083 - CD34
IPR013836 - CD34/Podocalyxin
Pfam Domains: PF06365 - CD34/Podocalyxin family
ModBase Predicted Comparative 3D Structure on P28906
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BX538076 - Homo sapiens mRNA; cDNA DKFZp686I22213 (from clone DKFZp686I22213).BC039146 - Homo sapiens CD34 molecule, mRNA (cDNA clone MGC:21247 IMAGE:4746591), complete cds.S53910 - CD34=glycoprotein expressed in lymphohematopoietic progenitor cells {alternatively spliced} [human, UT7 cells, mRNA, 2463 nt].S53911 - CD34=glycoprotein expressed in lymphohematopoietic progenitor cells {alternatively spliced, truncated form} [human, UT7, mRNA, 2657 nt].AK091890 - Homo sapiens cDNA FLJ34571 fis, clone KIDNE2008116, highly similar to HEMATOPOIETIC PROGENITOR CELL ANTIGEN CD34 PRECURSOR.LQ882868 - Sequence 17 from Patent WO2018160841.M81104 - Homo sapiens CD34 mRNA, complete cds.DM110847 - Novel Cancer Marker and Use Thereof.JD166224 - Sequence 147248 from Patent EP1572962.JD393887 - Sequence 374911 from Patent EP1572962.JD382744 - Sequence 363768 from Patent EP1572962.JD126706 - Sequence 107730 from Patent EP1572962.JD291205 - Sequence 272229 from Patent EP1572962.JD380020 - Sequence 361044 from Patent EP1572962.JD271220 - Sequence 252244 from Patent EP1572962.JD399665 - Sequence 380689 from Patent EP1572962.JD519444 - Sequence 500468 from Patent EP1572962.JD398450 - Sequence 379474 from Patent EP1572962.JD119661 - Sequence 100685 from Patent EP1572962.JD274064 - Sequence 255088 from Patent EP1572962.JD445218 - Sequence 426242 from Patent EP1572962.JD524484 - Sequence 505508 from Patent EP1572962.JD374113 - Sequence 355137 from Patent EP1572962.JD133172 - Sequence 114196 from Patent EP1572962.JD545681 - Sequence 526705 from Patent EP1572962.JD168988 - Sequence 150012 from Patent EP1572962.JD234319 - Sequence 215343 from Patent EP1572962.JD202705 - Sequence 183729 from Patent EP1572962.JD528843 - Sequence 509867 from Patent EP1572962.AK294381 - Homo sapiens cDNA FLJ53734 complete cds, highly similar to Hematopoietic progenitor cell antigen CD34 precursor.JD241940 - Sequence 222964 from Patent EP1572962.JD298204 - Sequence 279228 from Patent EP1572962.AK291529 - Homo sapiens cDNA FLJ78715 complete cds, highly similar to Homo sapiens CD34 antigen (CD34), transcript variant 1, mRNA.JD390293 - Sequence 371317 from Patent EP1572962.JD253490 - Sequence 234514 from Patent EP1572962.AK293030 - Homo sapiens cDNA FLJ75215 complete cds, highly similar to CD34=glycoprotein expressed in lymphohematopoietic progenitor cells.JD389631 - Sequence 370655 from Patent EP1572962.JD372720 - Sequence 353744 from Patent EP1572962.JD449810 - Sequence 430834 from Patent EP1572962.JD434864 - Sequence 415888 from Patent EP1572962.JD261648 - Sequence 242672 from Patent EP1572962.AF523361 - Homo sapiens CD34 antigen (CD34) mRNA, complete cds.JD402266 - Sequence 383290 from Patent EP1572962.JD120744 - Sequence 101768 from Patent EP1572962.JD264225 - Sequence 245249 from Patent EP1572962.AK300835 - Homo sapiens cDNA FLJ54166 complete cds, highly similar to Hematopoietic progenitor cell antigen CD34 precursor.DQ891428 - Synthetic construct clone IMAGE:100004058; FLH176854.01X; RZPDo839A03124D CD34 molecule (CD34) gene, encodes complete protein.DQ894603 - Synthetic construct Homo sapiens clone IMAGE:100009063; FLH176851.01L; RZPDo839A03123D CD34 molecule (CD34) gene, encodes complete protein.LQ493928 - Sequence 7 from Patent WO2016077734.JD394893 - Sequence 375917 from Patent EP1572962.JD213511 - Sequence 194535 from Patent EP1572962.AF202879 - Homo sapiens hematopoietic progenitor cell antigen CD34 precursor (CD34) mRNA, partial cds.JD390820 - Sequence 371844 from Patent EP1572962.JD285749 - Sequence 266773 from Patent EP1572962.JD278097 - Sequence 259121 from Patent EP1572962.JD392750 - Sequence 373774 from Patent EP1572962.JD397637 - Sequence 378661 from Patent EP1572962.JD389451 - Sequence 370475 from Patent EP1572962.JD252117 - Sequence 233141 from Patent EP1572962.JD338659 - Sequence 319683 from Patent EP1572962.JD416612 - Sequence 397636 from Patent EP1572962.JD080379 - Sequence 61403 from Patent EP1572962.JD328518 - Sequence 309542 from Patent EP1572962.AF538601 - Homo sapiens hematopoietic progenital cell antigen CD34 precursor (CD34) mRNA, partial cds.JD196354 - Sequence 177378 from Patent EP1572962.JD336618 - Sequence 317642 from Patent EP1572962.MP584518 - Sequence 17 from Patent WO2020081767.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04514 - Cell adhesion molecules (CAMs)hsa04640 - Hematopoietic cell lineage
BioCarta from NCI Cancer Genome Anatomy Project h_lympathway - Adhesion and Diapedesis of Lymphocytes
h_il17Pathway - IL 17 Signaling Pathway
Reactome (by CSHL, EBI, and GO) Protein P28906 (Reactome details) participates in the following event(s):R-HSA-199046 Ligands bind L-selectin
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
Other Names for This Gene
Alternate Gene Symbols: A8K664, CD34_HUMAN, ENST00000356522.1, ENST00000356522.2, ENST00000356522.3, NM_001773, P28906, Q15970, Q15971, Q5JTA3, Q5JTA4, Q9UJB1, uc001hgx.1, uc001hgx.2UCSC ID: ENST00000356522.4RefSeq Accession: NM_001773
Protein: P28906
(aka CD34_HUMAN)
CCDS: CCDS31012.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.