ID:SRP09_HUMAN DESCRIPTION: RecName: Full=Signal recognition particle 9 kDa protein; Short=SRP9; FUNCTION: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. SUBUNIT: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the SRP9 family. WEB RESOURCE: Name=Wikipedia; Note=Signal recognition particle entry; URL="http://en.wikipedia.org/wiki/Signal-recognition_particle";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49458
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation GO:0045900 negative regulation of translational elongation
Cellular Component: GO:0005737 cytoplasm GO:0005785 signal recognition particle receptor complex GO:0005786 signal recognition particle, endoplasmic reticulum targeting GO:0005829 cytosol GO:0048500 signal recognition particle
Descriptions from all associated GenBank mRNAs
KJ905928 - Synthetic construct Homo sapiens clone ccsbBroadEn_15598 SRP9 gene, encodes complete protein. KJ897603 - Synthetic construct Homo sapiens clone ccsbBroadEn_06997 SRP9 gene, encodes complete protein. KJ892198 - Synthetic construct Homo sapiens clone ccsbBroadEn_01592 SRP9 gene, encodes complete protein. BC066957 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone MGC:87436 IMAGE:5263635), complete cds. BC008443 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone MGC:14657 IMAGE:4102222), complete cds. EF488978 - Homo sapiens signal recognition particle 9 kDa isoform mRNA, complete cds. AF070649 - Homo sapiens clone 24452 mRNA sequence. U20998 - Homo sapiens signal recognition particle subunit 9 (SRP9) mRNA, complete cds. BC106005 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone MGC:110981 IMAGE:6026221), complete cds. BC021995 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone MGC:24524 IMAGE:4101294), complete cds. BC015094 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone MGC:22694 IMAGE:3930047), complete cds. AK289595 - Homo sapiens cDNA FLJ76514 complete cds, highly similar to Homo sapiens signal recognition particle 9kDa (SRP9), mRNA. BC045603 - Homo sapiens, clone IMAGE:4615687, mRNA. BC022415 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone MGC:24591 IMAGE:4243562), complete cds. BC064351 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone MGC:75133 IMAGE:4452218), complete cds. AL050363 - Homo sapiens mRNA; cDNA DKFZp564M2223 (from clone DKFZp564M2223). BC067845 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone MGC:87437 IMAGE:5287027), complete cds. JD506736 - Sequence 487760 from Patent EP1572962. DL491687 - Novel nucleic acids. BC070305 - Homo sapiens signal recognition particle 9kDa, mRNA (cDNA clone IMAGE:3829096), **** WARNING: chimeric clone ****. BC024171 - Homo sapiens mRNA similar to ribosomal protein L31 (cDNA clone IMAGE:4091831). DL491688 - Novel nucleic acids. DL490271 - Novel nucleic acids. BC017414 - Homo sapiens, Similar to signal recognition particle 9kD, clone IMAGE:4655251, mRNA, partial cds. JD314679 - Sequence 295703 from Patent EP1572962. JD022617 - Sequence 3641 from Patent EP1572962. JD168321 - Sequence 149345 from Patent EP1572962. JD046468 - Sequence 27492 from Patent EP1572962. JD184490 - Sequence 165514 from Patent EP1572962. JD197399 - Sequence 178423 from Patent EP1572962. JD298678 - Sequence 279702 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03060 - Protein export
Reactome (by CSHL, EBI, and GO)
Protein P49458 (Reactome details) participates in the following event(s):
R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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