Human Gene TRIM17 (ENST00000295033.7) Description and Page Index
  Description: May function as an ubiquitin E3 ligase. (from UniProt Q9Y577)
RefSeq Summary (NM_001024940): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000295033.7
Gencode Gene: ENSG00000162931.12
Transcript (Including UTRs)
   Position: hg38 chr1:228,408,036-228,416,664 Size: 8,629 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr1:228,408,201-228,415,072 Size: 6,872 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:228,408,036-228,416,664)mRNA (may differ from genome)Protein (477 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase TRIM17; EC=6.3.2.-; AltName: Full=RING finger protein 16; AltName: Full=Testis RING finger protein; AltName: Full=Tripartite motif-containing protein 17;
FUNCTION: May function as an ubiquitin E3 ligase.
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Interacts (via coiled coil) with TRIM44 (via coiled coil).
INTERACTION: Q9HCM9:TRIM39; NbExp=3; IntAct=EBI-743894, EBI-739510;
TISSUE SPECIFICITY: Almost exclusively in the testis.
PTM: Auto-ubiquitinated.
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

-  MalaCards Disease Associations
  MalaCards Gene Search: TRIM17
Diseases sorted by gene-association score: opitz-gbbb syndrome (7), branchiootic syndrome (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.06 RPKM in Testis
Total median expression: 131.45 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.00131-0.481 Picture PostScript Text
3' UTR -55.10165-0.334 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR018957 - Znf_C3HC4_RING-type
IPR001841 - Znf_RING
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00622 - SPRY domain
PF00643 - B-box zinc finger
PF00097 - Zinc finger, C3HC4 type (RING finger)

ModBase Predicted Comparative 3D Structure on Q9Y577
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0030674 protein binding, bridging
GO:0046872 metal ion binding

Biological Process:
GO:0006914 autophagy
GO:0016567 protein ubiquitination
GO:0032880 regulation of protein localization
GO:0051865 protein autoubiquitination

Cellular Component:
GO:0005575 cellular_component
GO:0005622 intracellular

-  Descriptions from all associated GenBank mRNAs
  AK055426 - Homo sapiens cDNA FLJ30864 fis, clone FEBRA2004091, highly similar to Tripartite motif-containing protein 17.
BC023999 - Homo sapiens cDNA clone IMAGE:4826445, containing frame-shift errors.
BC033788 - Homo sapiens tripartite motif-containing 17, mRNA (cDNA clone MGC:45102 IMAGE:5165609), complete cds.
AF156271 - Homo sapiens RING finger protein terf mRNA, complete cds.
KJ893828 - Synthetic construct Homo sapiens clone ccsbBroadEn_03222 TRIM17 gene, encodes complete protein.
AK308774 - Homo sapiens cDNA, FLJ98815.
AK301105 - Homo sapiens cDNA FLJ60354 complete cds, highly similar to Tripartite motif-containing protein 17.
AK316379 - Homo sapiens cDNA, FLJ79278 complete cds, highly similar to Tripartite motif-containing protein 17.
CU689740 - Synthetic construct Homo sapiens gateway clone IMAGE:100019583 5' read TRIM17 mRNA.
JD257837 - Sequence 238861 from Patent EP1572962.
JD399451 - Sequence 380475 from Patent EP1572962.
JD467287 - Sequence 448311 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y577 (Reactome details) participates in the following event(s):

R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B4DVJ2, BC033788, Q5VST8, Q9Y577, RBCC, RNF16, TERF, TRI17_HUMAN, uc001hsv.1, uc001hsv.2, uc001hsv.3, uc001hsv.4
UCSC ID: uc001hsv.4
RefSeq Accession: NM_001024940
Protein: Q9Y577 (aka TRI17_HUMAN or TM17_HUMAN)
CCDS: CCDS1571.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.