ID:M3KL4_HUMAN DESCRIPTION: RecName: Full=Mitogen-activated protein kinase kinase kinase MLK4; EC=2.7.11.25; AltName: Full=Mixed lineage kinase 4; FUNCTION: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation (By similarity). SUBUNIT: Homodimer (By similarity). Interacts with TLR4. PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAB47433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5TCX8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000186 activation of MAPKK activity GO:0006468 protein phosphorylation GO:0007256 activation of JNKK activity GO:0007257 activation of JUN kinase activity GO:0016310 phosphorylation GO:0046777 protein autophosphorylation