Human Gene NID1 (ENST00000264187.7) from GENCODE V44
Description: Homo sapiens nidogen 1 (NID1), mRNA. (from RefSeq NM_002508)
RefSeq Summary (NM_002508): This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000264187.7
Gencode Gene: ENSG00000116962.15
Transcript (Including UTRs)
Position: hg38 chr1:235,975,830-236,065,090 Size: 89,261 Total Exon Count: 20 Strand: -
Coding Region
Position: hg38 chr1:235,977,867-236,065,079 Size: 87,213 Coding Exon Count: 20
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: NID1_HUMAN
DESCRIPTION: RecName: Full=Nidogen-1; Short=NID-1; AltName: Full=Entactin; Flags: Precursor;
FUNCTION: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions.SUBUNIT: Interacts with FBLN1 and LGALS3BP (By similarity). Interacts with PLXDC1.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.PTM: N- and O-glycosylated.SIMILARITY: Contains 6 EGF-like domains.SIMILARITY: Contains 4 LDL-receptor class B repeats.SIMILARITY: Contains 1 NIDO domain.SIMILARITY: Contains 1 nidogen G2 beta-barrel domain.SIMILARITY: Contains 1 thyroglobulin type-1 domain.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011042 - 6-blade_b-propeller_TolB-like
IPR000742 - EG-like_dom
IPR001881 - EGF-like_Ca-bd
IPR013032 - EGF-like_CS
IPR000152 - EGF-type_Asp/Asn_hydroxyl_site
IPR018097 - EGF_Ca-bd_CS
IPR024731 - EGF_dom_MSP1-like
IPR006605 - G2_nidogen/fibulin_G2F
IPR009017 - Green_fluorescent_prot-like
IPR000033 - LDLR_classB_rpt
IPR003886 - Nidogen_extracell_dom
IPR000716 - Thyroglobulin_1
Pfam Domains: PF12947 - EGF domain
PF07645 - Calcium-binding EGF domain
PF07474 - G2F domain
PF00058 - Low-density lipoprotein receptor repeat class B
PF06119 - Nidogen-like
PF00086 - Thyroglobulin type-1 repeat
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P14543
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC045606 - Homo sapiens nidogen 1, mRNA (cDNA clone MGC:33141 IMAGE:5271590), complete cds.GQ891509 - Homo sapiens clone HEL-S-230 epididymis secretory sperm binding protein mRNA, complete cds.LF384899 - JP 2014500723-A/192402: Polycomb-Associated Non-Coding RNAs.MA620476 - JP 2018138019-A/192402: Polycomb-Associated Non-Coding RNAs.M30269 - Human nidogen mRNA, complete cds.AB209448 - Homo sapiens mRNA for nidogen (enactin) variant protein.AK297234 - Homo sapiens cDNA FLJ51241 complete cds, highly similar to Nidogen-1 precursor.CU692272 - Synthetic construct Homo sapiens gateway clone IMAGE:100021010 5' read NID1 mRNA.LF330968 - JP 2014500723-A/138471: Polycomb-Associated Non-Coding RNAs.MA566545 - JP 2018138019-A/138471: Polycomb-Associated Non-Coding RNAs.LF330967 - JP 2014500723-A/138470: Polycomb-Associated Non-Coding RNAs.MA566544 - JP 2018138019-A/138470: Polycomb-Associated Non-Coding RNAs.LF330966 - JP 2014500723-A/138469: Polycomb-Associated Non-Coding RNAs.MA566543 - JP 2018138019-A/138469: Polycomb-Associated Non-Coding RNAs.LF330965 - JP 2014500723-A/138468: Polycomb-Associated Non-Coding RNAs.MA566542 - JP 2018138019-A/138468: Polycomb-Associated Non-Coding RNAs.M27445 - Homo sapiens nidogen (NID) mRNA, 3' end.JD320337 - Sequence 301361 from Patent EP1572962.JD473689 - Sequence 454713 from Patent EP1572962.JD356156 - Sequence 337180 from Patent EP1572962.JD166452 - Sequence 147476 from Patent EP1572962.JD427139 - Sequence 408163 from Patent EP1572962.LF330962 - JP 2014500723-A/138465: Polycomb-Associated Non-Coding RNAs.MA566539 - JP 2018138019-A/138465: Polycomb-Associated Non-Coding RNAs.JD183343 - Sequence 164367 from Patent EP1572962.LF330961 - JP 2014500723-A/138464: Polycomb-Associated Non-Coding RNAs.MA566538 - JP 2018138019-A/138464: Polycomb-Associated Non-Coding RNAs.LF330959 - JP 2014500723-A/138462: Polycomb-Associated Non-Coding RNAs.MA566536 - JP 2018138019-A/138462: Polycomb-Associated Non-Coding RNAs.JD240907 - Sequence 221931 from Patent EP1572962.LF330958 - JP 2014500723-A/138461: Polycomb-Associated Non-Coding RNAs.MA566535 - JP 2018138019-A/138461: Polycomb-Associated Non-Coding RNAs.JD321819 - Sequence 302843 from Patent EP1572962.JD509313 - Sequence 490337 from Patent EP1572962.LF330956 - JP 2014500723-A/138459: Polycomb-Associated Non-Coding RNAs.MA566533 - JP 2018138019-A/138459: Polycomb-Associated Non-Coding RNAs.JD061850 - Sequence 42874 from Patent EP1572962.JD102475 - Sequence 83499 from Patent EP1572962.JD042255 - Sequence 23279 from Patent EP1572962.JD387365 - Sequence 368389 from Patent EP1572962.JD439440 - Sequence 420464 from Patent EP1572962.JD209917 - Sequence 190941 from Patent EP1572962.LF330954 - JP 2014500723-A/138457: Polycomb-Associated Non-Coding RNAs.MA566531 - JP 2018138019-A/138457: Polycomb-Associated Non-Coding RNAs.JD434059 - Sequence 415083 from Patent EP1572962.JD487392 - Sequence 468416 from Patent EP1572962.LF330953 - JP 2014500723-A/138456: Polycomb-Associated Non-Coding RNAs.MA566530 - JP 2018138019-A/138456: Polycomb-Associated Non-Coding RNAs.LF330950 - JP 2014500723-A/138453: Polycomb-Associated Non-Coding RNAs.MA566527 - JP 2018138019-A/138453: Polycomb-Associated Non-Coding RNAs.LF330948 - JP 2014500723-A/138451: Polycomb-Associated Non-Coding RNAs.MA566525 - JP 2018138019-A/138451: Polycomb-Associated Non-Coding RNAs.LF330945 - JP 2014500723-A/138448: Polycomb-Associated Non-Coding RNAs.MA566522 - JP 2018138019-A/138448: Polycomb-Associated Non-Coding RNAs.LF330943 - JP 2014500723-A/138446: Polycomb-Associated Non-Coding RNAs.MA566520 - JP 2018138019-A/138446: Polycomb-Associated Non-Coding RNAs.LF330941 - JP 2014500723-A/138444: Polycomb-Associated Non-Coding RNAs.MA566518 - JP 2018138019-A/138444: Polycomb-Associated Non-Coding RNAs.LF330940 - JP 2014500723-A/138443: Polycomb-Associated Non-Coding RNAs.MA566517 - JP 2018138019-A/138443: Polycomb-Associated Non-Coding RNAs.LF330939 - JP 2014500723-A/138442: Polycomb-Associated Non-Coding RNAs.MA566516 - JP 2018138019-A/138442: Polycomb-Associated Non-Coding RNAs.LF330938 - JP 2014500723-A/138441: Polycomb-Associated Non-Coding RNAs.MA566515 - JP 2018138019-A/138441: Polycomb-Associated Non-Coding RNAs.LF330937 - JP 2014500723-A/138440: Polycomb-Associated Non-Coding RNAs.MA566514 - JP 2018138019-A/138440: Polycomb-Associated Non-Coding RNAs.LF330935 - JP 2014500723-A/138438: Polycomb-Associated Non-Coding RNAs.MA566512 - JP 2018138019-A/138438: Polycomb-Associated Non-Coding RNAs.LF330934 - JP 2014500723-A/138437: Polycomb-Associated Non-Coding RNAs.MA566511 - JP 2018138019-A/138437: Polycomb-Associated Non-Coding RNAs.LF330932 - JP 2014500723-A/138435: Polycomb-Associated Non-Coding RNAs.MA566509 - JP 2018138019-A/138435: Polycomb-Associated Non-Coding RNAs.LF330931 - JP 2014500723-A/138434: Polycomb-Associated Non-Coding RNAs.MA566508 - JP 2018138019-A/138434: Polycomb-Associated Non-Coding RNAs.LF330929 - JP 2014500723-A/138432: Polycomb-Associated Non-Coding RNAs.MA566506 - JP 2018138019-A/138432: Polycomb-Associated Non-Coding RNAs.LF330927 - JP 2014500723-A/138430: Polycomb-Associated Non-Coding RNAs.MA566504 - JP 2018138019-A/138430: Polycomb-Associated Non-Coding RNAs.LF330926 - JP 2014500723-A/138429: Polycomb-Associated Non-Coding RNAs.MA566503 - JP 2018138019-A/138429: Polycomb-Associated Non-Coding RNAs.LF330925 - JP 2014500723-A/138428: Polycomb-Associated Non-Coding RNAs.MA566502 - JP 2018138019-A/138428: Polycomb-Associated Non-Coding RNAs.LF330924 - JP 2014500723-A/138427: Polycomb-Associated Non-Coding RNAs.MA566501 - JP 2018138019-A/138427: Polycomb-Associated Non-Coding RNAs.LF330922 - JP 2014500723-A/138425: Polycomb-Associated Non-Coding RNAs.MA566499 - JP 2018138019-A/138425: Polycomb-Associated Non-Coding RNAs.LF330920 - JP 2014500723-A/138423: Polycomb-Associated Non-Coding RNAs.MA566497 - JP 2018138019-A/138423: Polycomb-Associated Non-Coding RNAs.LF330919 - JP 2014500723-A/138422: Polycomb-Associated Non-Coding RNAs.MA566496 - JP 2018138019-A/138422: Polycomb-Associated Non-Coding RNAs.LF330918 - JP 2014500723-A/138421: Polycomb-Associated Non-Coding RNAs.MA566495 - JP 2018138019-A/138421: Polycomb-Associated Non-Coding RNAs.LF330917 - JP 2014500723-A/138420: Polycomb-Associated Non-Coding RNAs.MA566494 - JP 2018138019-A/138420: Polycomb-Associated Non-Coding RNAs.LF330916 - JP 2014500723-A/138419: Polycomb-Associated Non-Coding RNAs.MA566493 - JP 2018138019-A/138419: Polycomb-Associated Non-Coding RNAs.LF330915 - JP 2014500723-A/138418: Polycomb-Associated Non-Coding RNAs.MA566492 - JP 2018138019-A/138418: Polycomb-Associated Non-Coding RNAs.BC012501 - Homo sapiens nidogen 1, mRNA (cDNA clone IMAGE:4513545), with apparent retained intron.LF213302 - JP 2014500723-A/20805: Polycomb-Associated Non-Coding RNAs.MA448879 - JP 2018138019-A/20805: Polycomb-Associated Non-Coding RNAs.LF209685 - JP 2014500723-A/17188: Polycomb-Associated Non-Coding RNAs.MA445262 - JP 2018138019-A/17188: Polycomb-Associated Non-Coding RNAs.LF330900 - JP 2014500723-A/138403: Polycomb-Associated Non-Coding RNAs.MA566477 - JP 2018138019-A/138403: Polycomb-Associated Non-Coding RNAs.LF330909 - JP 2014500723-A/138412: Polycomb-Associated Non-Coding RNAs.MA566486 - JP 2018138019-A/138412: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000264187.1, ENST00000264187.2, ENST00000264187.3, ENST00000264187.4, ENST00000264187.5, ENST00000264187.6, NID, NID1_HUMAN, NM_002508, P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7, uc001hxo.1, uc001hxo.2, uc001hxo.3, uc001hxo.4, uc001hxo.5UCSC ID: ENST00000264187.7RefSeq Accession: NM_002508
Protein: P14543
(aka NID1_HUMAN)
CCDS: CCDS1608.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.