Human Gene GTPBP4 (ENST00000360803.9) from GENCODE V44
  Description: Homo sapiens GTP binding protein 4 (GTPBP4), mRNA. (from RefSeq NM_012341)
RefSeq Summary (NM_012341): GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000360803.9
Gencode Gene: ENSG00000107937.19
Transcript (Including UTRs)
   Position: hg38 chr10:988,434-1,019,932 Size: 31,499 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg38 chr10:988,480-1,017,227 Size: 28,748 Coding Exon Count: 17 

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RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:988,434-1,019,932)mRNA (may differ from genome)Protein (634 aa)
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-  Comments and Description Text from UniProtKB
  ID: NOG1_HUMAN
DESCRIPTION: RecName: Full=Nucleolar GTP-binding protein 1; AltName: Full=Chronic renal failure gene protein; AltName: Full=GTP-binding protein NGB;
FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit (By similarity).
INTERACTION: P35240:NF2; NbExp=9; IntAct=EBI-1056249, EBI-1014472;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: Belongs to the GTP1/OBG family. NOG subfamily.

-  Primer design for this transcript
 

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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GTPBP4
Diseases sorted by gene-association score: commensal bacterial infectious disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D016572 Cyclosporine
  • D004997 Ethinyl Estradiol
  • D013749 Tetrachlorodibenzodioxin
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C035207 4-amino-2,6-dinitrotoluene
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.62 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 386.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.5046-0.315 Picture PostScript Text
3' UTR -843.202705-0.312 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006073 - GTP_binding_domain
IPR024926 - NOG1
IPR010674 - NOG1_Rossman_fold_dom
IPR012973 - NOG_C
IPR005225 - Small_GTP-bd_dom

Pfam Domains:
PF06858 - Nucleolar GTP-binding protein 1 (NOG1)
PF08155 - NOGCT (NUC087) domain

ModBase Predicted Comparative 3D Structure on Q9BZE4
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
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Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
AlignmentAlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding

Biological Process:
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001649 osteoblast differentiation
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell proliferation
GO:0022408 negative regulation of cell-cell adhesion
GO:0030336 negative regulation of cell migration
GO:0031397 negative regulation of protein ubiquitination
GO:0033342 negative regulation of collagen binding
GO:0042254 ribosome biogenesis
GO:0050821 protein stabilization

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK001552 - Homo sapiens cDNA FLJ10690 fis, clone NT2RP3000350, weakly similar to PROBABLE GTP-BINDING PROTEIN HP0303.
BC008683 - Homo sapiens GTP binding protein 4, mRNA (cDNA clone IMAGE:3870299), with apparent retained intron.
BC021243 - Homo sapiens GTP binding protein 4, mRNA (cDNA clone IMAGE:4139481), partial cds.
AF120334 - Homo sapiens GTP-binding protein NGB mRNA, complete cds.
BC038975 - Homo sapiens GTP binding protein 4, mRNA (cDNA clone MGC:47676 IMAGE:5534986), complete cds.
AK097093 - Homo sapiens cDNA FLJ39774 fis, clone SPLEN2001367, highly similar to Homo sapiens GTP-binding protein NGB mRNA.
AK295231 - Homo sapiens cDNA FLJ53992 complete cds, highly similar to Nucleolar GTP-binding protein 1.
AK001548 - Homo sapiens cDNA FLJ10686 fis, clone NT2RP3000252, highly similar to Nucleolar GTP-binding protein 1.
AK222861 - Homo sapiens mRNA for G protein-binding protein CRFG variant, clone: HEP15729.
KJ898511 - Synthetic construct Homo sapiens clone ccsbBroadEn_07905 GTPBP4 gene, encodes complete protein.
AF325353 - Homo sapiens G protein-binding protein CRFG (CRFG) mRNA, complete cds.
BC033784 - Homo sapiens GTP binding protein 4, mRNA (cDNA clone IMAGE:4474374), partial cds.
AK302219 - Homo sapiens cDNA FLJ56266 complete cds, highly similar to Nucleolar GTP-binding protein 1.
AK301721 - Homo sapiens cDNA FLJ55652 complete cds, highly similar to Nucleolar GTP-binding protein 1.
JD224101 - Sequence 205125 from Patent EP1572962.
JD225911 - Sequence 206935 from Patent EP1572962.
JD440004 - Sequence 421028 from Patent EP1572962.
JD502171 - Sequence 483195 from Patent EP1572962.
JD379828 - Sequence 360852 from Patent EP1572962.
BC040651 - Homo sapiens isopentenyl-diphosphate delta isomerase 2, mRNA (cDNA clone IMAGE:4795541).
JD344157 - Sequence 325181 from Patent EP1572962.
JD144744 - Sequence 125768 from Patent EP1572962.
JD277887 - Sequence 258911 from Patent EP1572962.
JD483532 - Sequence 464556 from Patent EP1572962.
JD047887 - Sequence 28911 from Patent EP1572962.
JD517865 - Sequence 498889 from Patent EP1572962.
JD478257 - Sequence 459281 from Patent EP1572962.
JD431721 - Sequence 412745 from Patent EP1572962.
JD165861 - Sequence 146885 from Patent EP1572962.
JD243119 - Sequence 224143 from Patent EP1572962.
JD155955 - Sequence 136979 from Patent EP1572962.
JD366772 - Sequence 347796 from Patent EP1572962.
JD316908 - Sequence 297932 from Patent EP1572962.
JD311000 - Sequence 292024 from Patent EP1572962.
JD254007 - Sequence 235031 from Patent EP1572962.
JD530192 - Sequence 511216 from Patent EP1572962.
JD344611 - Sequence 325635 from Patent EP1572962.
JD226116 - Sequence 207140 from Patent EP1572962.
JD199156 - Sequence 180180 from Patent EP1572962.
JD172912 - Sequence 153936 from Patent EP1572962.
JD321886 - Sequence 302910 from Patent EP1572962.
CU676059 - Synthetic construct Homo sapiens gateway clone IMAGE:100022144 3' read IDI2 mRNA.
JD310733 - Sequence 291757 from Patent EP1572962.
JD054862 - Sequence 35886 from Patent EP1572962.
JD214960 - Sequence 195984 from Patent EP1572962.
JD224996 - Sequence 206020 from Patent EP1572962.
JD507507 - Sequence 488531 from Patent EP1572962.
JD049604 - Sequence 30628 from Patent EP1572962.
JD306070 - Sequence 287094 from Patent EP1572962.
JD297277 - Sequence 278301 from Patent EP1572962.
JD048082 - Sequence 29106 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KMC5, CRFG, ENST00000360803.1, ENST00000360803.2, ENST00000360803.3, ENST00000360803.4, ENST00000360803.5, ENST00000360803.6, ENST00000360803.7, ENST00000360803.8, NM_012341, NOG1, NOG1_HUMAN, O95446, Q5T3R8, Q9BZE4, Q9NVJ8, uc001ift.1, uc001ift.2, uc001ift.3, uc001ift.4, uc001ift.5
UCSC ID: ENST00000360803.9
RefSeq Accession: NM_012341
Protein: Q9BZE4 (aka NOG1_HUMAN)
CCDS: CCDS31132.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.