Human Gene GTPBP4 (ENST00000360803.9) from GENCODE V44
Description: Homo sapiens GTP binding protein 4 (GTPBP4), mRNA. (from RefSeq NM_012341) RefSeq Summary (NM_012341): GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000360803.9 Gencode Gene: ENSG00000107937.19 Transcript (Including UTRs) Position: hg38 chr10:988,434-1,019,932 Size: 31,499 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr10:988,480-1,017,227 Size: 28,748 Coding Exon Count: 17
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZE4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.