Human Gene P4HA1 (ENST00000307116.6) from GENCODE V44
Description: Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. (from UniProt P13674) RefSeq Summary (NM_001017962): This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000307116.6 Gencode Gene: ENSG00000122884.13 Transcript (Including UTRs) Position: hg38 chr10:73,007,217-73,096,850 Size: 89,634 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr10:73,008,222-73,074,883 Size: 66,662 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P13674
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004656 procollagen-proline 4-dioxygenase activity GO:0005506 iron ion binding GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0031418 L-ascorbic acid binding GO:0042802 identical protein binding GO:0046872 metal ion binding GO:0051213 dioxygenase activity
Biological Process: GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline GO:0030199 collagen fibril organization GO:0055114 oxidation-reduction process
US Server
