Human Gene SFTPD (ENST00000372292.8) from GENCODE V44
Description: Homo sapiens surfactant protein D (SFTPD), mRNA. (from RefSeq NM_003019) RefSeq Summary (NM_003019): The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]. Gencode Transcript: ENST00000372292.8 Gencode Gene: ENSG00000133661.17 Transcript (Including UTRs) Position: hg38 chr10:79,937,740-79,949,105 Size: 11,366 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr10:79,937,852-79,946,659 Size: 8,808 Coding Exon Count: 7
ID:SFTPD_HUMAN DESCRIPTION: RecName: Full=Pulmonary surfactant-associated protein D; Short=PSP-D; Short=SP-D; AltName: Full=Collectin-7; AltName: Full=Lung surfactant protein D; Flags: Precursor; FUNCTION: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. SUBUNIT: Oligomeric complex of 4 set of homotrimers. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. PTM: The N-terminus is blocked. PTM: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates (By similarity). MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C). SIMILARITY: Belongs to the SFTPD family. SIMILARITY: Contains 1 C-type lectin domain. SIMILARITY: Contains 1 collagen-like domain. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/sftpd/"; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Pulmonary surfactant protein SP-D; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_228";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35247
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001817 regulation of cytokine production GO:0002224 toll-like receptor signaling pathway GO:0002376 immune system process GO:0006898 receptor-mediated endocytosis GO:0007585 respiratory gaseous exchange GO:0042130 negative regulation of T cell proliferation GO:0042742 defense response to bacterium GO:0043129 surfactant homeostasis GO:0043152 induction of bacterial agglutination GO:0044267 cellular protein metabolic process GO:0045085 negative regulation of interleukin-2 biosynthetic process GO:0045087 innate immune response GO:0048246 macrophage chemotaxis GO:0048286 lung alveolus development GO:0050766 positive regulation of phagocytosis GO:0050776 regulation of immune response GO:0052405 negative regulation by host of symbiont molecular function GO:0072593 reactive oxygen species metabolic process GO:1905226 regulation of adhesion of symbiont to host epithelial cell
US Server
