Human Gene HHEX (ENST00000282728.10) from GENCODE V44
Description: Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA. (from RefSeq NM_002729) RefSeq Summary (NM_002729): This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000282728.10 Gencode Gene: ENSG00000152804.11 Transcript (Including UTRs) Position: hg38 chr10:92,689,955-92,695,647 Size: 5,693 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr10:92,689,987-92,694,768 Size: 4,782 Coding Exon Count: 4
ID:HHEX_HUMAN DESCRIPTION: RecName: Full=Hematopoietically-expressed homeobox protein HHEX; Short=Homeobox protein HEX; AltName: Full=Homeobox protein PRH; FUNCTION: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Liver and promyelocytic leukemia cell line HL- 60. DEVELOPMENTAL STAGE: Expressed during hematopoiesis. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q03014
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0008190 eukaryotic initiation factor 4E binding GO:0008301 DNA binding, bending GO:0017025 TBP-class protein binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0070491 repressing transcription factor binding GO:0071837 HMG box domain binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001570 vasculogenesis GO:0001701 in utero embryonic development GO:0001889 liver development GO:0002009 morphogenesis of an epithelium GO:0002573 myeloid leukocyte differentiation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006406 mRNA export from nucleus GO:0007165 signal transduction GO:0007219 Notch signaling pathway GO:0007275 multicellular organism development GO:0007492 endoderm development GO:0008283 cell proliferation GO:0009611 response to wounding GO:0009887 animal organ morphogenesis GO:0009952 anterior/posterior pattern specification GO:0010621 negative regulation of transcription by transcription factor localization GO:0010944 negative regulation of transcription by competitive promoter binding GO:0016055 Wnt signaling pathway GO:0016525 negative regulation of angiogenesis GO:0016973 poly(A)+ mRNA export from nucleus GO:0022027 interkinetic nuclear migration GO:0030097 hemopoiesis GO:0030154 cell differentiation GO:0030177 positive regulation of Wnt signaling pathway GO:0030183 B cell differentiation GO:0030878 thyroid gland development GO:0030900 forebrain development GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0031016 pancreas development GO:0034504 protein localization to nucleus GO:0035050 embryonic heart tube development GO:0035264 multicellular organism growth GO:0042127 regulation of cell proliferation GO:0043434 response to peptide hormone GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048568 embryonic organ development GO:0048729 tissue morphogenesis GO:0048853 forebrain morphogenesis GO:0060431 primary lung bud formation GO:0061009 common bile duct development GO:0061010 gall bladder development GO:0061011 hepatic duct development GO:0061017 hepatoblast differentiation GO:0070365 hepatocyte differentiation GO:0071103 DNA conformation change GO:0090009 primitive streak formation