Human Gene LOXL4 (ENST00000260702.4) from GENCODE V44
Description: Homo sapiens lysyl oxidase like 4 (LOXL4), mRNA. (from RefSeq NM_032211) RefSeq Summary (NM_032211): This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000260702.4 Gencode Gene: ENSG00000138131.4 Transcript (Including UTRs) Position: hg38 chr10:98,247,690-98,268,194 Size: 20,505 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr10:98,248,921-98,263,019 Size: 14,099 Coding Exon Count: 14
ID:LOXL4_HUMAN DESCRIPTION: RecName: Full=Lysyl oxidase homolog 4; EC=1.4.3.-; AltName: Full=Lysyl oxidase-like protein 4; AltName: Full=Lysyl oxidase-related protein C; Flags: Precursor; FUNCTION: May modulate the formation of a collagenous extracellular matrix. COFACTOR: Copper (By similarity). COFACTOR: Contains 1 lysine tyrosylquinone (By similarity). INTERACTION: Q15645:TRIP13; NbExp=3; IntAct=EBI-749562, EBI-358993; SUBCELLULAR LOCATION: Secreted, extracellular space (Potential). TISSUE SPECIFICITY: Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage. PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. SIMILARITY: Belongs to the lysyl oxidase family. SIMILARITY: Contains 4 SRCR domains. SEQUENCE CAUTION: Sequence=AAH07522.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LOXL4ID41193ch10q24.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96JB6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005044 scavenger receptor activity GO:0005507 copper ion binding GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0046872 metal ion binding
Biological Process: GO:0006898 receptor-mediated endocytosis GO:0055114 oxidation-reduction process
US Server
