Human Gene POLL (ENST00000339310.7) from GENCODE V44
Description: DNA polymerase lambda (from HGNC POLL)
RefSeq Summary (NM_001174084): This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010].
Gencode Transcript: ENST00000339310.7
Gencode Gene: ENSG00000166169.17
Transcript (Including UTRs)
Position: hg38 chr10:101,578,882-101,588,126 Size: 9,245 Total Exon Count: 5 Strand: -
Coding Region
Position: hg38 chr10:101,579,453-101,587,305 Size: 7,853 Coding Exon Count: 5
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002054 - DNA-dir_DNA_pol_X
IPR010996 - DNA-dir_DNA_pol_X_beta-like_N
IPR019843 - DNA_pol-X_BS
IPR018944 - DNA_pol_lambd_fingers_domain
IPR022312 - DNA_pol_X
IPR002008 - DNA_pol_X_beta-like
IPR000445 - HhH_motif
IPR003583 - Hlx-hairpin-Hlx_DNA-bd_motif
Pfam Domains: PF10391 - Fingers domain of DNA polymerase lambda
PF00633 - Helix-hairpin-helix motif
ModBase Predicted Comparative 3D Structure on Q5JQP4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK128521 - Homo sapiens cDNA FLJ46679 fis, clone TRACH3010331, highly similar to Homo sapiens polymerase (DNA directed), lambda (POLL).LF211349 - JP 2014500723-A/18852: Polycomb-Associated Non-Coding RNAs.MA446926 - JP 2018138019-A/18852: Polycomb-Associated Non-Coding RNAs.AF218027 - Homo sapiens clone PP712 unknown mRNA.AF161019 - Homo sapiens DNA polymerase lambda (Pol lambda) mRNA, complete cds.BC003548 - Homo sapiens polymerase (DNA directed), lambda, mRNA (cDNA clone MGC:1149 IMAGE:3536366), complete cds.BC068529 - Homo sapiens polymerase (DNA directed), lambda, mRNA (cDNA clone MGC:87359 IMAGE:5267859), complete cds.AJ131890 - Homo sapiens mRNA for DNA polymerase lambda (POLL gene).AK094956 - Homo sapiens cDNA FLJ37637 fis, clone BRCOC2018877, highly similar to Homo sapiens mRNA for DNA polymerase lambda (POLL gene).AK091106 - Homo sapiens cDNA FLJ33787 fis, clone BRSSN2009119.AX746781 - Sequence 306 from Patent EP1308459.AK127896 - Homo sapiens cDNA FLJ46002 fis, clone SMINT2011509, highly similar to DNA polymerase lambda (EC 2.7.7.7).AK022476 - Homo sapiens cDNA FLJ12414 fis, clone MAMMA1003013, weakly similar to DNA POLYMERASE BETA (EC 2.7.7.7).AK021600 - Homo sapiens cDNA FLJ11538 fis, clone HEMBA1002746, weakly similar to DNA POLYMERASE BETA (EC 2.7.7.7).AK293602 - Homo sapiens cDNA FLJ55191 complete cds, highly similar to DNA polymerase lambda (EC 2.7.7.7).AK292225 - Homo sapiens cDNA FLJ77175 complete cds, highly similar to Homo sapiens DNA polymerase lamda2 mRNA.AK293421 - Homo sapiens cDNA FLJ53301 complete cds, highly similar to DNA polymerase lambda (EC 2.7.7.7).AK300862 - Homo sapiens cDNA FLJ54038 complete cds, highly similar to DNA polymerase lambda (EC 2.7.7.7).AF283478 - Homo sapiens DNA polymerase beta2 mRNA, complete cds.AY302442 - Homo sapiens DNA polymerase lamda2 mRNA, complete cds.KJ902471 - Synthetic construct Homo sapiens clone ccsbBroadEn_11865 POLL gene, encodes complete protein.AB384717 - Synthetic construct DNA, clone: pF1KB3002, Homo sapiens POLL gene for DNA polymerase lambda, complete cds, without stop codon, in Flexi system.AJ844641 - Homo sapiens partial mRNA for DNA polymerase lambda (POLL gene).JD220226 - Sequence 201250 from Patent EP1572962.JD219309 - Sequence 200333 from Patent EP1572962.JD086265 - Sequence 67289 from Patent EP1572962.JD108915 - Sequence 89939 from Patent EP1572962.JD453409 - Sequence 434433 from Patent EP1572962.JD483756 - Sequence 464780 from Patent EP1572962.JD210546 - Sequence 191570 from Patent EP1572962.JD300712 - Sequence 281736 from Patent EP1572962.JD068676 - Sequence 49700 from Patent EP1572962.JD205550 - Sequence 186574 from Patent EP1572962.JD260928 - Sequence 241952 from Patent EP1572962.JD122378 - Sequence 103402 from Patent EP1572962.JD383569 - Sequence 364593 from Patent EP1572962.JD216537 - Sequence 197561 from Patent EP1572962.LF345799 - JP 2014500723-A/153302: Polycomb-Associated Non-Coding RNAs.MA581376 - JP 2018138019-A/153302: Polycomb-Associated Non-Coding RNAs.JD170035 - Sequence 151059 from Patent EP1572962.JD325019 - Sequence 306043 from Patent EP1572962.JD224692 - Sequence 205716 from Patent EP1572962.JD054119 - Sequence 35143 from Patent EP1572962.JD209152 - Sequence 190176 from Patent EP1572962.JD348599 - Sequence 329623 from Patent EP1572962.AJ844640 - Homo sapiens partial POLL pseudogene mRNA.AJ844642 - Homo sapiens partial mRNA for DNA polymerase lambda, shorter clone (POLL gene).LF345800 - JP 2014500723-A/153303: Polycomb-Associated Non-Coding RNAs.MA581377 - JP 2018138019-A/153303: Polycomb-Associated Non-Coding RNAs.LF345801 - JP 2014500723-A/153304: Polycomb-Associated Non-Coding RNAs.MA581378 - JP 2018138019-A/153304: Polycomb-Associated Non-Coding RNAs.LF345803 - JP 2014500723-A/153306: Polycomb-Associated Non-Coding RNAs.MA581380 - JP 2018138019-A/153306: Polycomb-Associated Non-Coding RNAs.LF345804 - JP 2014500723-A/153307: Polycomb-Associated Non-Coding RNAs.MA581381 - JP 2018138019-A/153307: Polycomb-Associated Non-Coding RNAs.JD022893 - Sequence 3917 from Patent EP1572962.JD029775 - Sequence 10799 from Patent EP1572962.AK293657 - Homo sapiens cDNA FLJ54109 complete cds, weakly similar to DNA polymerase lambda (EC 2.7.7.7).LF345807 - JP 2014500723-A/153310: Polycomb-Associated Non-Coding RNAs.MA581384 - JP 2018138019-A/153310: Polycomb-Associated Non-Coding RNAs.LF345808 - JP 2014500723-A/153311: Polycomb-Associated Non-Coding RNAs.MA581385 - JP 2018138019-A/153311: Polycomb-Associated Non-Coding RNAs.JD538151 - Sequence 519175 from Patent EP1572962.JD114814 - Sequence 95838 from Patent EP1572962.JD187648 - Sequence 168672 from Patent EP1572962.JD200581 - Sequence 181605 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03410 - Base excision repairhsa03450 - Non-homologous end-joining
Other Names for This Gene
Alternate Gene Symbols: BC003548, ENST00000339310.1, ENST00000339310.2, ENST00000339310.3, ENST00000339310.4, ENST00000339310.5, ENST00000339310.6, Q5JQP4, Q5JQP4_HUMAN, RP11-529I10.1-010, uc001kth.1, uc001kth.2UCSC ID: ENST00000339310.7RefSeq Accession: NM_001174084
Protein: Q5JQP4
CCDS: CCDS76332.1
Methods, Credits, and Use Restrictions
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