Human Gene PSD (uc001kvh.2) Description and Page Index
Description: Homo sapiens pleckstrin and Sec7 domain containing (PSD), transcript variant 3, mRNA. RefSeq Summary (NM_001270966): This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. Transcript (Including UTRs) Position: hg19 chr10:104,162,374-104,179,484 Size: 17,111 Total Exon Count: 18 Strand: - Coding Region Position: hg19 chr10:104,162,957-104,173,941 Size: 10,985 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A5PKW4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.