Human Gene TRIM8 (ENST00000643721.1) Description and Page Index
Description: Homo sapiens tripartite motif containing 8 (TRIM8), transcript variant 1, mRNA. (from RefSeq NM_030912) RefSeq Summary (NM_030912): This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000643721.1 Gencode Gene: ENSG00000171206.14 Transcript (Including UTRs) Position: hg38 chr10:102,642,310-102,660,680 Size: 18,371 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr10:102,644,618-102,657,354 Size: 12,737 Coding Exon Count: 6
ID:TRIM8_HUMAN DESCRIPTION: RecName: Full=Probable E3 ubiquitin-protein ligase TRIM8; EC=6.3.2.-; AltName: Full=Glioblastoma-expressed RING finger protein; AltName: Full=RING finger protein 27; AltName: Full=Tripartite motif-containing protein 8; FUNCTION: Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box (By similarity). INTERACTION: Self; NbExp=2; IntAct=EBI-2340370, EBI-2340370; TISSUE SPECIFICITY: Widely expressed. DOMAIN: The coiled coil domain is required for homodimerization. DOMAIN: The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1 (By similarity). SIMILARITY: Belongs to the TRIM/RBCC family. SIMILARITY: Contains 2 B box-type zinc fingers. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00097 - Zinc finger, C3HC4 type (RING finger)
ModBase Predicted Comparative 3D Structure on Q9BZR9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.