Human Gene GSTO1 (ENST00000369713.10) from GENCODE V44
  Description: Homo sapiens glutathione S-transferase omega 1 (GSTO1), transcript variant 1, mRNA. (from RefSeq NM_004832)
RefSeq Summary (NM_004832): The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Gencode Transcript: ENST00000369713.10
Gencode Gene: ENSG00000148834.13
Transcript (Including UTRs)
   Position: hg38 chr10:104,254,892-104,267,455 Size: 12,564 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr10:104,254,929-104,267,405 Size: 12,477 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:104,254,892-104,267,455)mRNA (may differ from genome)Protein (241 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GSTO1
Diseases sorted by gene-association score: proliferative type fibrocystic change of breast (17), intracystic papillary adenoma (16), cavernous sinus meningioma (11), patella, chondromalacia of (11), facial neuralgia (9), cavernous sinus thrombosis (8), thoracic outlet syndrome (7), trigeminal nerve disease (7), chondromalacia (7), trigeminal neuralgia (5), parkinson disease, late-onset (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 85.16 RPKM in Liver
Total median expression: 1882.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.9037-0.214 Picture PostScript Text
3' UTR -10.7050-0.214 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Descriptions from all associated GenBank mRNAs
  BX537431 - Homo sapiens mRNA; cDNA DKFZp686H13163 (from clone DKFZp686H13163); complete cds.
AK313680 - Homo sapiens cDNA, FLJ94267, highly similar to Homo sapiens glutathione S-transferase omega 1 (GSTO1), mRNA.
BC000127 - Homo sapiens glutathione S-transferase omega 1, mRNA (cDNA clone MGC:1503 IMAGE:3351359), complete cds.
AF212303 - Homo sapiens glutathione transferase omega (GSTO1) mRNA, complete cds.
EU794619 - Homo sapiens epididymis secretory protein Li 21 (HEL-S-21) mRNA, complete cds.
U90313 - Human glutathione-S-transferase homolog mRNA, complete cds.
AB590772 - Synthetic construct DNA, clone: pFN21AE1734, Homo sapiens GSTO1 gene for glutathione S-transferase omega 1, without stop codon, in Flexi system.
KJ892771 - Synthetic construct Homo sapiens clone ccsbBroadEn_02165 GSTO1 gene, encodes complete protein.
KR709755 - Synthetic construct Homo sapiens clone CCSBHm_00005695 GSTO1 (GSTO1) mRNA, encodes complete protein.
U56250 - Human HeLa mRNA isolated as a false positive in a two-hybrid-screen.
JD477581 - Sequence 458605 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00480 - Glutathione metabolism
hsa00980 - Metabolism of xenobiotics by cytochrome P450
hsa00982 - Drug metabolism - cytochrome P450

BioCyc Knowledge Library
PWY-6370 - ascorbate recycling (cytosolic)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000369713.1, ENST00000369713.2, ENST00000369713.3, ENST00000369713.4, ENST00000369713.5, ENST00000369713.6, ENST00000369713.7, ENST00000369713.8, ENST00000369713.9, NM_004832, uc001kya.1, uc001kya.2, uc001kya.3, uc001kya.4, uc001kya.5, V9HWG9
UCSC ID: ENST00000369713.10
RefSeq Accession: NM_004832
CCDS: CCDS7555.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.