Human Gene GPAM (ENST00000348367.9) from GENCODE V44
Description: Homo sapiens glycerol-3-phosphate acyltransferase, mitochondrial (GPAM), transcript variant 2, mRNA. (from RefSeq NM_020918) RefSeq Summary (NM_001244949): This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000348367.9 Gencode Gene: ENSG00000119927.14 Transcript (Including UTRs) Position: hg38 chr10:112,149,865-112,183,765 Size: 33,901 Total Exon Count: 22 Strand: - Coding Region Position: hg38 chr10:112,153,550-112,181,784 Size: 28,235 Coding Exon Count: 20
ID:GPAT1_HUMAN DESCRIPTION: RecName: Full=Glycerol-3-phosphate acyltransferase 1, mitochondrial; Short=GPAT-1; EC=2.3.1.15; Flags: Precursor; FUNCTION: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. CATALYTIC ACTIVITY: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate. PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein (By similarity). DOMAIN: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity). SIMILARITY: Belongs to the GPAT/DAPAT family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCL2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006637 acyl-CoA metabolic process GO:0006641 triglyceride metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006654 phosphatidic acid biosynthetic process GO:0008152 metabolic process GO:0008654 phospholipid biosynthetic process GO:0009749 response to glucose GO:0016024 CDP-diacylglycerol biosynthetic process GO:0019432 triglyceride biosynthetic process GO:0033146 regulation of intracellular estrogen receptor signaling pathway GO:0040018 positive regulation of multicellular organism growth GO:0042104 positive regulation of activated T cell proliferation GO:0044255 cellular lipid metabolic process GO:0045540 regulation of cholesterol biosynthetic process GO:0050707 regulation of cytokine secretion GO:0051607 defense response to virus GO:0055089 fatty acid homeostasis GO:0055091 phospholipid homeostasis GO:0070236 negative regulation of activation-induced cell death of T cells GO:0070970 interleukin-2 secretion
US Server
