Human Gene PNLIP (ENST00000369221.2) from GENCODE V44
Description: Homo sapiens pancreatic lipase (PNLIP), mRNA. (from RefSeq NM_000936) RefSeq Summary (NM_000936): This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. [provided by RefSeq, Jul 2016]. Gencode Transcript: ENST00000369221.2 Gencode Gene: ENSG00000175535.6 Transcript (Including UTRs) Position: hg38 chr10:116,545,931-116,567,855 Size: 21,925 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr10:116,546,093-116,567,798 Size: 21,706 Coding Exon Count: 12
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16233
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.