Human Gene RNH1 (ENST00000534797.5) from GENCODE V44
Description: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. (from UniProt P13489) RefSeq Summary (NM_203385): Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]. Gencode Transcript: ENST00000534797.5 Gencode Gene: ENSG00000023191.17 Transcript (Including UTRs) Position: hg38 chr11:494,512-503,570 Size: 9,059 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr11:494,691-502,162 Size: 7,472 Coding Exon Count: 9
ID:RINI_HUMAN DESCRIPTION: RecName: Full=Ribonuclease inhibitor; AltName: Full=Placental ribonuclease inhibitor; Short=Placental RNase inhibitor; AltName: Full=Ribonuclease/angiogenin inhibitor 1; Short=RAI; FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. SUBUNIT: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2. INTERACTION: P03950:ANG; NbExp=2; IntAct=EBI-1237106, EBI-525291; P07998:RNASE1; NbExp=2; IntAct=EBI-1237106, EBI-2823523; P61823:RNASE1 (xeno); NbExp=3; IntAct=EBI-1237106, EBI-908364; SUBCELLULAR LOCATION: Cytoplasm. DOMAIN: The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNAses via a large protein interaction surface on its interior side. PTM: The N-terminus is blocked. PTM: At least 30 of the 32 cysteine residues are in the reduced form. SIMILARITY: Contains 15 LRR (leucine-rich) repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P13489
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
