Human Gene OSBPL5 (ENST00000389989.7) from GENCODE V44
Description: Homo sapiens oxysterol binding protein like 5 (OSBPL5), transcript variant 2, mRNA. (from RefSeq NM_145638) RefSeq Summary (NM_145638): This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]. Gencode Transcript: ENST00000389989.7 Gencode Gene: ENSG00000021762.20 Transcript (Including UTRs) Position: hg38 chr11:3,087,121-3,165,300 Size: 78,180 Total Exon Count: 21 Strand: - Coding Region Position: hg38 chr11:3,088,205-3,129,148 Size: 40,944 Coding Exon Count: 20
ID:OSBL5_HUMAN DESCRIPTION: RecName: Full=Oxysterol-binding protein-related protein 5; Short=ORP-5; Short=OSBP-related protein 5; AltName: Full=Oxysterol-binding protein homolog 1; FUNCTION: May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. TISSUE SPECIFICITY: Ubiquitously expressed. MISCELLANEOUS: The gene is imprinted in placenta, where it is predominantly expressed from the maternal allele only. Not imprinted in other tissues. SIMILARITY: Belongs to the OSBP family. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=BAA96058.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01237 - Oxysterol-binding protein PF00169 - PH domain
ModBase Predicted Comparative 3D Structure on Q9H0X9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006869 lipid transport GO:0006893 Golgi to plasma membrane transport GO:0008203 cholesterol metabolic process GO:0015914 phospholipid transport GO:0030301 cholesterol transport GO:0036150 phosphatidylserine acyl-chain remodeling
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