Human Gene FHIP1B (ENST00000449352.7) from GENCODE V44
Description: Homo sapiens family with sequence similarity 160 member A2 (FAM160A2), transcript variant 2, mRNA. (from RefSeq NM_001098794) RefSeq Summary (NM_001098794): The protein encoded by this gene is part of the FTS/Hook/FHIP (FHF) complex, which can interact with members of the homotypic vesicular protein sorting (HOPS) complex. This interaction suggests that the encoded protein is involved in vesicle trafficking. [provided by RefSeq, Dec 2016]. Gencode Transcript: ENST00000449352.7 Gencode Gene: ENSG00000051009.11 Transcript (Including UTRs) Position: hg38 chr11:6,211,345-6,234,636 Size: 23,292 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr11:6,211,506-6,224,516 Size: 13,011 Coding Exon Count: 11
ID:F16A2_HUMAN DESCRIPTION: RecName: Full=FTS and Hook-interacting protein; Short=FHIP; AltName: Full=Protein FAM160A2; FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). SUBUNIT: Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). SIMILARITY: Belongs to the UPF0518 family. SEQUENCE CAUTION: Sequence=BAB21850.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10257 - Retinoic acid induced 16-like protein
ModBase Predicted Comparative 3D Structure on Q8N612
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007032 endosome organization GO:0007040 lysosome organization GO:0008333 endosome to lysosome transport GO:0015031 protein transport GO:0045022 early endosome to late endosome transport
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