Human Gene TRIM3 (ENST00000345851.8) Description and Page Index
  Description: Homo sapiens tripartite motif containing 3 (TRIM3), transcript variant 2, mRNA. (from RefSeq NM_033278)
RefSeq Summary (NM_033278): The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000345851.8
Gencode Gene: ENSG00000110171.20
Transcript (Including UTRs)
   Position: hg38 chr11:6,448,613-6,473,941 Size: 25,329 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr11:6,449,028-6,465,695 Size: 16,668 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:6,448,613-6,473,941)mRNA (may differ from genome)Protein (744 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 3; AltName: Full=Brain-expressed RING finger protein; AltName: Full=RING finger protein 22; AltName: Full=RING finger protein 97;
FUNCTION: Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
SUBUNIT: Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with ZFYVE28/LST2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Early endosome.
TISSUE SPECIFICITY: Expressed in brain, heart, uterus and testis.
DOMAIN: The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades (By similarity).
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 filamin repeat.
SIMILARITY: Contains 6 NHL repeats.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.20 RPKM in Brain - Cerebellum
Total median expression: 422.61 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.20188-0.533 Picture PostScript Text
3' UTR -147.90415-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011042 - 6-blade_b-propeller_TolB-like
IPR003649 - Bbox_C
IPR001298 - Filamin
IPR017868 - Filamin/ABP280_repeat-like
IPR013783 - Ig-like_fold
IPR014756 - Ig_E-set
IPR001258 - NHL_repeat
IPR013017 - NHL_repeat_subgr
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00630 - Filamin/ABP280 repeat
PF01436 - NHL repeat
PF00643 - B-box zinc finger

ModBase Predicted Comparative 3D Structure on O75382
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0007399 nervous system development
GO:0015031 protein transport
GO:0016567 protein ubiquitination

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0030425 dendrite
GO:0042995 cell projection

-  Descriptions from all associated GenBank mRNAs
  AL122053 - Homo sapiens mRNA; cDNA DKFZp434N1221 (from clone DKFZp434N1221).
AK122682 - Homo sapiens cDNA FLJ16135 fis, clone BRACE2045445, highly similar to Tripartite motif-containing protein 3.
AK299586 - Homo sapiens cDNA FLJ56028 complete cds, highly similar to Tripartite motif-containing protein 3.
AK126685 - Homo sapiens cDNA FLJ44731 fis, clone BRACE3025719, highly similar to Homo sapiens ring finger protein 22 (RNF22).
AK291396 - Homo sapiens cDNA FLJ75494 complete cds, highly similar to Homo sapiens tripartite motif-containing 3 (TRIM3), transcript variant 2, mRNA.
BC096827 - Homo sapiens tripartite motif-containing 3, mRNA (cDNA clone MGC:111679 IMAGE:6108991), complete cds.
AK127278 - Homo sapiens cDNA FLJ45345 fis, clone BRHIP3010529, highly similar to Homo sapiens tripartite motif-containing 3 (TRIM3).
AK298843 - Homo sapiens cDNA FLJ55875 complete cds, highly similar to Tripartite motif-containing protein 3.
AF045239 - Homo sapiens brain expressed ring finger protein mRNA, complete cds.
AF220020 - Homo sapiens tripartite motif protein TRIM3 isoform alpha (TRIM3) mRNA, complete cds; alternatively spliced.
AF220021 - Homo sapiens tripartite motif protein TRIM3 isoform beta (TRIM3) mRNA, complete cds; alternatively spliced.
AF220022 - Homo sapiens tripartite motif protein TRIM3 isoform gamma (TRIM3) mRNA, complete cds; alternatively spliced.
KJ898256 - Synthetic construct Homo sapiens clone ccsbBroadEn_07650 TRIM3 gene, encodes complete protein.
AB385160 - Synthetic construct DNA, clone: pF1KB5705, Homo sapiens TRIM3 gene for tripartite motif-containing protein 3, complete cds, without stop codon, in Flexi system.
AL360192 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 787957.
AL360185 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 186783.
AK311127 - Homo sapiens cDNA, FLJ18169.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75382 (Reactome details) participates in the following event(s):

R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: BERP, NM_033278, O75382, Q4V9L4, Q9C038, Q9C039, RNF22, RNF97, TRIM3_HUMAN, uc001mdi.1, uc001mdi.2, uc001mdi.3, uc001mdi.4, uc001mdi.5
UCSC ID: uc001mdi.5
RefSeq Accession: NM_033278
Protein: O75382 (aka TRIM3_HUMAN or TRM3_HUMAN)
CCDS: CCDS7764.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.