Human Gene TRIM3 (ENST00000345851.8) Description and Page Index
  Description: Homo sapiens tripartite motif containing 3 (TRIM3), transcript variant 2, mRNA. (from RefSeq NM_033278)
RefSeq Summary (NM_033278): The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000345851.8
Gencode Gene: ENSG00000110171.20
Transcript (Including UTRs)
   Position: hg38 chr11:6,448,613-6,473,941 Size: 25,329 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr11:6,449,028-6,465,695 Size: 16,668 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:6,448,613-6,473,941)mRNA (may differ from genome)Protein (744 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TRIM3_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 3; AltName: Full=Brain-expressed RING finger protein; AltName: Full=RING finger protein 22; AltName: Full=RING finger protein 97;
FUNCTION: Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
SUBUNIT: Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with ZFYVE28/LST2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Early endosome.
TISSUE SPECIFICITY: Expressed in brain, heart, uterus and testis.
DOMAIN: The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades (By similarity).
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 filamin repeat.
SIMILARITY: Contains 6 NHL repeats.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.20 RPKM in Brain - Cerebellum
Total median expression: 422.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.20188-0.533 Picture PostScript Text
3' UTR -147.90415-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011042 - 6-blade_b-propeller_TolB-like
IPR003649 - Bbox_C
IPR001298 - Filamin
IPR017868 - Filamin/ABP280_repeat-like
IPR013783 - Ig-like_fold
IPR014756 - Ig_E-set
IPR001258 - NHL_repeat
IPR013017 - NHL_repeat_subgr
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00630 - Filamin/ABP280 repeat
PF01436 - NHL repeat
PF00643 - B-box zinc finger

ModBase Predicted Comparative 3D Structure on O75382
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0007399 nervous system development
GO:0015031 protein transport
GO:0016567 protein ubiquitination

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0030425 dendrite
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  AL122053 - Homo sapiens mRNA; cDNA DKFZp434N1221 (from clone DKFZp434N1221).
AK122682 - Homo sapiens cDNA FLJ16135 fis, clone BRACE2045445, highly similar to Tripartite motif-containing protein 3.
AK299586 - Homo sapiens cDNA FLJ56028 complete cds, highly similar to Tripartite motif-containing protein 3.
AK126685 - Homo sapiens cDNA FLJ44731 fis, clone BRACE3025719, highly similar to Homo sapiens ring finger protein 22 (RNF22).
AK291396 - Homo sapiens cDNA FLJ75494 complete cds, highly similar to Homo sapiens tripartite motif-containing 3 (TRIM3), transcript variant 2, mRNA.
BC096827 - Homo sapiens tripartite motif-containing 3, mRNA (cDNA clone MGC:111679 IMAGE:6108991), complete cds.
AK127278 - Homo sapiens cDNA FLJ45345 fis, clone BRHIP3010529, highly similar to Homo sapiens tripartite motif-containing 3 (TRIM3).
AK298843 - Homo sapiens cDNA FLJ55875 complete cds, highly similar to Tripartite motif-containing protein 3.
AF045239 - Homo sapiens brain expressed ring finger protein mRNA, complete cds.
AF220020 - Homo sapiens tripartite motif protein TRIM3 isoform alpha (TRIM3) mRNA, complete cds; alternatively spliced.
AF220021 - Homo sapiens tripartite motif protein TRIM3 isoform beta (TRIM3) mRNA, complete cds; alternatively spliced.
AF220022 - Homo sapiens tripartite motif protein TRIM3 isoform gamma (TRIM3) mRNA, complete cds; alternatively spliced.
KJ898256 - Synthetic construct Homo sapiens clone ccsbBroadEn_07650 TRIM3 gene, encodes complete protein.
AB385160 - Synthetic construct DNA, clone: pF1KB5705, Homo sapiens TRIM3 gene for tripartite motif-containing protein 3, complete cds, without stop codon, in Flexi system.
AL360192 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 787957.
AL360185 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 186783.
AK311127 - Homo sapiens cDNA, FLJ18169.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75382 (Reactome details) participates in the following event(s):

R-HSA-877300 Interferon gamma signaling
R-HSA-913531 Interferon Signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: BERP, NM_033278, O75382, Q4V9L4, Q9C038, Q9C039, RNF22, RNF97, TRIM3_HUMAN, uc001mdi.1, uc001mdi.2, uc001mdi.3, uc001mdi.4, uc001mdi.5
UCSC ID: uc001mdi.5
RefSeq Accession: NM_033278
Protein: O75382 (aka TRIM3_HUMAN or TRM3_HUMAN)
CCDS: CCDS7764.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.