Human Gene TRIM3 (ENST00000345851.8) Description and Page Index
Description: Homo sapiens tripartite motif containing 3 (TRIM3), transcript variant 2, mRNA. (from RefSeq NM_033278) RefSeq Summary (NM_033278): The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000345851.8 Gencode Gene: ENSG00000110171.20 Transcript (Including UTRs) Position: hg38 chr11:6,448,613-6,473,941 Size: 25,329 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr11:6,449,028-6,465,695 Size: 16,668 Coding Exon Count: 11
ID:TRIM3_HUMAN DESCRIPTION: RecName: Full=Tripartite motif-containing protein 3; AltName: Full=Brain-expressed RING finger protein; AltName: Full=RING finger protein 22; AltName: Full=RING finger protein 97; FUNCTION: Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. SUBUNIT: Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) (By similarity). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with ZFYVE28/LST2. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Early endosome. TISSUE SPECIFICITY: Expressed in brain, heart, uterus and testis. DOMAIN: The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades (By similarity). SIMILARITY: Belongs to the TRIM/RBCC family. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 filamin repeat. SIMILARITY: Contains 6 NHL repeats. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75382
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.