ID:UBP47_HUMAN DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase 47; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 47; AltName: Full=Ubiquitin thioesterase 47; AltName: Full=Ubiquitin-specific-processing protease 47; FUNCTION: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). SUBUNIT: Interacts with BTRC and FBXW11. Interacts with POLB. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed in skeletal muscle, heart and testis. SIMILARITY: Belongs to the peptidase C19 family. CAUTION: Was initially thought to catalytically inactive (PubMed:14715245). However, it was later shown that it is active (PubMed:21362556). SEQUENCE CAUTION: Sequence=BAA91348.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96K76
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006284 base-excision repair GO:0006508 proteolysis GO:0006511 ubiquitin-dependent protein catabolic process GO:0006974 cellular response to DNA damage stimulus GO:0010972 negative regulation of G2/M transition of mitotic cell cycle GO:0016579 protein deubiquitination GO:0030307 positive regulation of cell growth GO:0034644 cellular response to UV GO:0035520 monoubiquitinated protein deubiquitination GO:0042493 response to drug GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045892 negative regulation of transcription, DNA-templated GO:0090263 positive regulation of canonical Wnt signaling pathway GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage