Human Gene KIF18A (ENST00000263181.7) from GENCODE V44
Description: Homo sapiens kinesin family member 18A (KIF18A), mRNA. (from RefSeq NM_031217) RefSeq Summary (NM_031217): KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]. Gencode Transcript: ENST00000263181.7 Gencode Gene: ENSG00000121621.7 Transcript (Including UTRs) Position: hg38 chr11:28,020,619-28,108,156 Size: 87,538 Total Exon Count: 17 Strand: - Coding Region Position: hg38 chr11:28,021,200-28,097,947 Size: 76,748 Coding Exon Count: 16
ID:KI18A_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF18A; AltName: Full=Marrow stromal KIF18A; Short=MS-KIF18A; FUNCTION: Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. SUBUNIT: Interacts with CENPE and ESR1. SUBCELLULAR LOCATION: Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. INDUCTION: By estrogen. PTM: Glycosylated. PTM: Ubiquitinated. SIMILARITY: Belongs to the kinesin-like protein family. SIMILARITY: Contains 1 kinesin-motor domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NI77
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0007019 microtubule depolymerization GO:0007080 mitotic metaphase plate congression GO:0007140 male meiosis GO:0015031 protein transport GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0070507 regulation of microtubule cytoskeleton organization GO:0071392 cellular response to estradiol stimulus GO:0072520 seminiferous tubule development
AB062483 - Homo sapiens OK/SW-cl.108 mRNA, complete cds. AY791349 - Homo sapiens kinesin-related protein (KIF18A) mRNA, complete cds. AL136819 - Homo sapiens mRNA; cDNA DKFZp434G2226 (from clone DKFZp434G2226). AK093850 - Homo sapiens cDNA FLJ36531 fis, clone TRACH2004336, weakly similar to PUTATIVE KINESIN-LIKE PROTEIN C2F12.13. AX748337 - Sequence 1862 from Patent EP1308459. BC048347 - Homo sapiens kinesin family member 18A, mRNA (cDNA clone MGC:51752 IMAGE:5576803), complete cds. AK312576 - Homo sapiens cDNA, FLJ92951, highly similar to Homo sapiens kinesin family member 18A (KIF18A), mRNA. AM393105 - Synthetic construct Homo sapiens clone IMAGE:100001967 for hypothetical protein (KIF18A gene). BC026090 - Homo sapiens kinesin family member 18A, mRNA (cDNA clone IMAGE:4839252), partial cds. LF205812 - JP 2014500723-A/13315: Polycomb-Associated Non-Coding RNAs. MA441389 - JP 2018138019-A/13315: Polycomb-Associated Non-Coding RNAs. JD302870 - Sequence 283894 from Patent EP1572962. JD436130 - Sequence 417154 from Patent EP1572962. JD043203 - Sequence 24227 from Patent EP1572962. JD084334 - Sequence 65358 from Patent EP1572962. BC035917 - Homo sapiens kinesin family member 18A, mRNA (cDNA clone IMAGE:5521364), with apparent retained intron.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8NI77 (Reactome details) participates in the following event(s):
R-HSA-984609 Kinesin-8 is a dimer R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-983266 Kinesins bind microtubules R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-983189 Kinesins R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-109582 Hemostasis R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2132295 MHC class II antigen presentation R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-1280218 Adaptive Immune System R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-168256 Immune System R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
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