Human Gene MADD (ENST00000342922.8) from GENCODE V44
Description: Homo sapiens MAP kinase activating death domain (MADD), transcript variant 1, mRNA. (from RefSeq NM_130470) RefSeq Summary (NM_130470): Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000342922.8 Gencode Gene: ENSG00000110514.20 Transcript (Including UTRs) Position: hg38 chr11:47,269,376-47,330,031 Size: 60,656 Total Exon Count: 33 Strand: + Coding Region Position: hg38 chr11:47,273,915-47,329,150 Size: 55,236 Coding Exon Count: 32
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
