Human Gene SLC43A1 (ENST00000528450.5) from GENCODE V44
Description: Homo sapiens solute carrier family 43 member 1 (SLC43A1), transcript variant 2, mRNA. (from RefSeq NM_001198810) RefSeq Summary (NM_001198810): SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000528450.5 Gencode Gene: ENSG00000149150.9 Transcript (Including UTRs) Position: hg38 chr11:57,484,536-57,514,885 Size: 30,350 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr11:57,485,096-57,514,111 Size: 29,016 Coding Exon Count: 14
ID:LAT3_HUMAN DESCRIPTION: RecName: Full=Large neutral amino acids transporter small subunit 3; AltName: Full=L-type amino acid transporter 3; AltName: Full=Prostate cancer overexpressed gene 1 protein; AltName: Full=Solute carrier family 43 member 1; FUNCTION: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells. MISCELLANEOUS: Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors. SIMILARITY: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07690 - Major Facilitator Superfamily
ModBase Predicted Comparative 3D Structure on O75387
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003333 amino acid transmembrane transport GO:0006865 amino acid transport GO:0015804 neutral amino acid transport GO:0055085 transmembrane transport GO:1902475 L-alpha-amino acid transmembrane transport
AB103033 - Homo sapiens lat3 mRNA for L-type amino acid transporter 3, complete cds. AF045584 - Homo sapiens PB39 mRNA, complete cds. BC001639 - Homo sapiens solute carrier family 43, member 1, mRNA (cDNA clone MGC:1944 IMAGE:2959372), complete cds. AK027732 - Homo sapiens cDNA FLJ14826 fis, clone OVARC1000850, highly similar to Large neutral amino acids transporter small subunit 3. JD227822 - Sequence 208846 from Patent EP1572962. JD141931 - Sequence 122955 from Patent EP1572962. JD276641 - Sequence 257665 from Patent EP1572962. JD318028 - Sequence 299052 from Patent EP1572962. KJ892546 - Synthetic construct Homo sapiens clone ccsbBroadEn_01940 SLC43A1 gene, encodes complete protein. CU674802 - Synthetic construct Homo sapiens gateway clone IMAGE:100017701 5' read SLC43A1 mRNA. JD520240 - Sequence 501264 from Patent EP1572962. JD077827 - Sequence 58851 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75387 (Reactome details) participates in the following event(s):
R-HSA-352103 Metabolism of nitrogenous molecules R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-425374 Amino acid and oligopeptide SLC transporters R-HSA-425393 Metabolism of nitrogenous molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
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