Human Gene WDR74 (ENST00000529106.5) from GENCODE V44
Description: Homo sapiens WD repeat domain 74 (WDR74), transcript variant 1, mRNA. (from RefSeq NM_018093)
Gencode Transcript: ENST00000529106.5
Gencode Gene: ENSG00000133316.16
Transcript (Including UTRs)
Position: hg38 chr11:62,832,912-62,840,156 Size: 7,245 Total Exon Count: 12 Strand: -
Coding Region
Position: hg38 chr11:62,832,952-62,839,570 Size: 6,619 Coding Exon Count: 11
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: WDR74_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 74; AltName: Full=NOP seven-associated protein 1;
SUBCELLULAR LOCATION: Nucleus, nucleolus.SIMILARITY: Contains 6 WD repeats.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom
Pfam Domains: PF00400 - WD domain, G-beta repeat
ModBase Predicted Comparative 3D Structure on Q6RFH5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF211226 - JP 2014500723-A/18729: Polycomb-Associated Non-Coding RNAs.MA446803 - JP 2018138019-A/18729: Polycomb-Associated Non-Coding RNAs.AK025383 - Homo sapiens cDNA: FLJ21730 fis, clone COLF1557.AY500828 - Homo sapiens NOP seven associated protein 1 (NSA1) mRNA, complete cds.BC006351 - Homo sapiens WD repeat domain 74, mRNA (cDNA clone MGC:12596 IMAGE:4111690), complete cds.AK001301 - Homo sapiens cDNA FLJ10439 fis, clone NT2RP1000688.AK292330 - Homo sapiens cDNA FLJ78749 complete cds, highly similar to Homo sapiens WD repeat domain 74 (WDR74), mRNA.HQ447879 - Synthetic construct Homo sapiens clone IMAGE:100071229; CCSB004913_02 WD repeat domain 74 (WDR74) gene, encodes complete protein.KJ902676 - Synthetic construct Homo sapiens clone ccsbBroadEn_12070 WDR74 gene, encodes complete protein.LF344739 - JP 2014500723-A/152242: Polycomb-Associated Non-Coding RNAs.MA580316 - JP 2018138019-A/152242: Polycomb-Associated Non-Coding RNAs.LF344738 - JP 2014500723-A/152241: Polycomb-Associated Non-Coding RNAs.MA580315 - JP 2018138019-A/152241: Polycomb-Associated Non-Coding RNAs.LF344736 - JP 2014500723-A/152239: Polycomb-Associated Non-Coding RNAs.MA580313 - JP 2018138019-A/152239: Polycomb-Associated Non-Coding RNAs.CU675359 - Synthetic construct Homo sapiens gateway clone IMAGE:100019098 5' read WDR74 mRNA.LF344735 - JP 2014500723-A/152238: Polycomb-Associated Non-Coding RNAs.MA580312 - JP 2018138019-A/152238: Polycomb-Associated Non-Coding RNAs.LF344734 - JP 2014500723-A/152237: Polycomb-Associated Non-Coding RNAs.MA580311 - JP 2018138019-A/152237: Polycomb-Associated Non-Coding RNAs.LF344732 - JP 2014500723-A/152235: Polycomb-Associated Non-Coding RNAs.MA580309 - JP 2018138019-A/152235: Polycomb-Associated Non-Coding RNAs.AK303186 - Homo sapiens cDNA FLJ57690 complete cds, highly similar to WD repeat protein 74.LF344731 - JP 2014500723-A/152234: Polycomb-Associated Non-Coding RNAs.MA580308 - JP 2018138019-A/152234: Polycomb-Associated Non-Coding RNAs.LF344729 - JP 2014500723-A/152232: Polycomb-Associated Non-Coding RNAs.MA580306 - JP 2018138019-A/152232: Polycomb-Associated Non-Coding RNAs.LF344726 - JP 2014500723-A/152229: Polycomb-Associated Non-Coding RNAs.MA580303 - JP 2018138019-A/152229: Polycomb-Associated Non-Coding RNAs.LF344725 - JP 2014500723-A/152228: Polycomb-Associated Non-Coding RNAs.MA580302 - JP 2018138019-A/152228: Polycomb-Associated Non-Coding RNAs.JD171047 - Sequence 152071 from Patent EP1572962.JD083683 - Sequence 64707 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A8K8G5, ENST00000529106.1, ENST00000529106.2, ENST00000529106.3, ENST00000529106.4, NM_018093, NSA1, Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2, uc001nvm.1, uc001nvm.2, uc001nvm.3, WDR74_HUMANUCSC ID: ENST00000529106.5RefSeq Accession: NM_018093
Protein: Q6RFH5
(aka WDR74_HUMAN)
CCDS: CCDS44630.1 , CCDS76421.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.