Human Gene ARL2 (ENST00000246747.9) from GENCODE V44
  Description: Homo sapiens ADP ribosylation factor like GTPase 2 (ARL2), transcript variant 1, mRNA. (from RefSeq NM_001667)
RefSeq Summary (NM_001667): This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000246747.9
Gencode Gene: ENSG00000213465.8
Transcript (Including UTRs)
   Position: hg38 chr11:65,014,160-65,022,184 Size: 8,025 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr11:65,014,208-65,021,855 Size: 7,648 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:65,014,160-65,022,184)mRNA (may differ from genome)Protein (184 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q53YD8_HUMAN
DESCRIPTION: SubName: Full=ADP-ribosylation factor-like 2; SubName: Full=ADP-ribosylation factor-like 2 variant; SubName: Full=HCG23373, isoform CRA_a;
SIMILARITY: Belongs to the small GTPase superfamily. Arf family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ARL2
Diseases sorted by gene-association score: deafness, autosomal recessive 88 (5), retinitis pigmentosa 66 (3), hypoparathyroidism-retardation-dysmorphism syndrome (2), retinitis pigmentosa (1), joubert syndrome 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 175.87 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 4319.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.5048-0.385 Picture PostScript Text
3' UTR -120.80329-0.367 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR024156 - Small_GTPase_ARF
IPR006689 - Small_GTPase_ARF/SAR

Pfam Domains:
PF00025 - ADP-ribosylation factor family

ModBase Predicted Comparative 3D Structure on Q53YD8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005525 GTP binding

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005925 focal adhesion


-  Descriptions from all associated GenBank mRNAs
  AK223502 - Homo sapiens mRNA for ADP-ribosylation factor-like 2 variant, clone: FCC121D06.
BC002530 - Homo sapiens ADP-ribosylation factor-like 2, mRNA (cDNA clone MGC:1800 IMAGE:3140402), complete cds.
AK096447 - Homo sapiens cDNA FLJ39128 fis, clone NTONG2007658, highly similar to Sorting nexin-15.
L13687 - Homo sapiens ADP-ribosylation factor-like protein 2 (ARL2) mRNA, complete cds.
JD215061 - Sequence 196085 from Patent EP1572962.
EU832750 - Synthetic construct Homo sapiens clone HAIB:100067779; DKFZo004H0432 ADP-ribosylation factor-like 2 protein (ARL2) gene, encodes complete protein.
EU832671 - Synthetic construct Homo sapiens clone HAIB:100067700; DKFZo008H0431 ADP-ribosylation factor-like 2 protein (ARL2) gene, encodes complete protein.
AB527923 - Synthetic construct DNA, clone: pF1KB0953, Homo sapiens ARL2 gene for ADP-ribosylation factor-like 2, without stop codon, in Flexi system.
AK294580 - Homo sapiens cDNA FLJ58989 complete cds, moderately similar to ADP-ribosylation factor-like protein 2.
KJ890710 - Synthetic construct Homo sapiens clone ccsbBroadEn_00104 ARL2 gene, encodes complete protein.
BT006674 - Homo sapiens ADP-ribosylation factor-like 2 mRNA, complete cds.
AF493888 - Homo sapiens ADP-ribosylation factor-like protein 2 (ARL2) mRNA, complete cds.
JD042960 - Sequence 23984 from Patent EP1572962.
JD320245 - Sequence 301269 from Patent EP1572962.
JD339071 - Sequence 320095 from Patent EP1572962.
JD286960 - Sequence 267984 from Patent EP1572962.
JD220490 - Sequence 201514 from Patent EP1572962.
JD383670 - Sequence 364694 from Patent EP1572962.
JD126644 - Sequence 107668 from Patent EP1572962.
JD058604 - Sequence 39628 from Patent EP1572962.
JD253326 - Sequence 234350 from Patent EP1572962.
JD389484 - Sequence 370508 from Patent EP1572962.
JD272645 - Sequence 253669 from Patent EP1572962.
JD423415 - Sequence 404439 from Patent EP1572962.
JD458779 - Sequence 439803 from Patent EP1572962.
JD198544 - Sequence 179568 from Patent EP1572962.
JD175293 - Sequence 156317 from Patent EP1572962.
JD066115 - Sequence 47139 from Patent EP1572962.
JD339939 - Sequence 320963 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000246747.1, ENST00000246747.2, ENST00000246747.3, ENST00000246747.4, ENST00000246747.5, ENST00000246747.6, ENST00000246747.7, ENST00000246747.8, hCG_23373, NM_001667, Q53YD8, Q53YD8_HUMAN, uc001och.1, uc001och.2, uc001och.3, uc001och.4, uc001och.5, uc001och.6
UCSC ID: ENST00000246747.9
RefSeq Accession: NM_001667
Protein: Q53YD8 CCDS: CCDS8088.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.