The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01222 - Ergosterol biosynthesis ERG4/ERG24 family
ModBase Predicted Comparative 3D Structure on O76062
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0016491 oxidoreductase activity GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0050613 delta14-sterol reductase activity GO:0050661 NADP binding
Biological Process: GO:0006629 lipid metabolic process GO:0006694 steroid biosynthetic process GO:0006695 cholesterol biosynthetic process GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0016126 sterol biosynthetic process GO:0045540 regulation of cholesterol biosynthetic process GO:0055114 oxidation-reduction process
Cellular Component: GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0030176 integral component of endoplasmic reticulum membrane GO:0031090 organelle membrane GO:0043231 intracellular membrane-bounded organelle GO:0043235 receptor complex GO:0005637 nuclear inner membrane
Descriptions from all associated GenBank mRNAs
LF211187 - JP 2014500723-A/18690: Polycomb-Associated Non-Coding RNAs. MA446764 - JP 2018138019-A/18690: Polycomb-Associated Non-Coding RNAs. AK290935 - Homo sapiens cDNA FLJ77103 complete cds, highly similar to Homo sapiens transmembrane 7 superfamily member 2, mRNA. AK296441 - Homo sapiens cDNA FLJ60622 complete cds, highly similar to Delta(14)-sterol reductase (EC 1.3.1.70). BC038353 - Homo sapiens transmembrane 7 superfamily member 2, mRNA (cDNA clone MGC:9089 IMAGE:3861907), complete cds. BC009052 - Homo sapiens transmembrane 7 superfamily member 2, mRNA (cDNA clone MGC:9286 IMAGE:3874367), complete cds. AF096304 - Homo sapiens putative sterol reductase SR-1 (TM7SF2) mRNA, complete cds. AF023676 - Homo sapiens lamin B receptor homolog TM7SF2 (TM7SF2) mRNA, complete cds. JD520423 - Sequence 501447 from Patent EP1572962. BC012857 - Homo sapiens transmembrane 7 superfamily member 2, mRNA (cDNA clone MGC:17157 IMAGE:4214662), complete cds. LF344482 - JP 2014500723-A/151985: Polycomb-Associated Non-Coding RNAs. MA580059 - JP 2018138019-A/151985: Polycomb-Associated Non-Coding RNAs. JD495951 - Sequence 476975 from Patent EP1572962. JD443957 - Sequence 424981 from Patent EP1572962. CU680420 - Synthetic construct Homo sapiens gateway clone IMAGE:100019307 5' read TM7SF2 mRNA. CU679239 - Synthetic construct Homo sapiens gateway clone IMAGE:100019309 5' read TM7SF2 mRNA. KJ905942 - Synthetic construct Homo sapiens clone ccsbBroadEn_15612 TM7SF2 gene, encodes complete protein. KJ897686 - Synthetic construct Homo sapiens clone ccsbBroadEn_07080 TM7SF2 gene, encodes complete protein. JD190926 - Sequence 171950 from Patent EP1572962. JD472885 - Sequence 453909 from Patent EP1572962. LF344479 - JP 2014500723-A/151982: Polycomb-Associated Non-Coding RNAs. MA580056 - JP 2018138019-A/151982: Polycomb-Associated Non-Coding RNAs. JD131639 - Sequence 112663 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-6074 - zymosterol biosynthesis PWY66-3 - cholesterol biosynthesis II (via 24,25-dihydrolanosterol) PWY66-341 - cholesterol biosynthesis I PWY66-4 - cholesterol biosynthesis III (via desmosterol) PWY66-5 - superpathway of cholesterol biosynthesis
Reactome (by CSHL, EBI, and GO)
Protein O76062 (Reactome details) participates in the following event(s):
R-HSA-194698 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-191273 Cholesterol biosynthesis R-HSA-8957322 Metabolism of steroids R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism
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