ID:PKHB1_HUMAN DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family B member 1; Short=PH domain-containing family B member 1; AltName: Full=Evectin-1; AltName: Full=PH domain-containing protein in retina 1; Short=PHRET1; AltName: Full=Pleckstrin homology domain retinal protein 1; FUNCTION: Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). SUBUNIT: Homodimer. Interacts (via PH domain) with MYO1C. Interacts (via PH domain) with MYO7A (By similarity). Binds transducins. SUBCELLULAR LOCATION: Membrane. Cytoplasm (By similarity). Note=Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. TISSUE SPECIFICITY: Highly expressed in retina and brain. Levels are very low or not detectable in all other tissues tested. SIMILARITY: Contains 1 PH domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UF11
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.