Human Gene NOX4 (uc001pcw.3) Description and Page Index
Description: Homo sapiens NADPH oxidase 4 (NOX4), transcript variant 4, non-coding RNA.
Transcript (Including UTRs)
Position: hg19 chr11:89,057,522-89,224,653 Size: 167,132 Total Exon Count: 9 Strand: -
Position: hg19 chr11:89,059,924-89,224,414 Size: 164,491 Coding Exon Count: 9
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive):
NOX4 CDC HuGE Published Literature:
NOX4 Positive Disease Associations: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Aleksey Shatunov et al. Lancet neurology 2010, Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study., Lancet neurology.
We have found strong evidence of a genetic association of two single nucleotide polymorphisms on chromosome 9 with sporadic ALS, in line with findings from previous independent GWAS of ALS and linkage studies of ALS-frontotemporal dementia. Our findings together with these earlier findings suggest that genetic variation at this locus on chromosome 9 causes sporadic ALS and familial ALS-frontotemporal dementia. Resequencing studies and then functional analysis should be done to identify the defective gene.
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF08030 - Ferric reductase NAD binding domain
SCOP Domains: 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
ModBase Predicted Comparative 3D Structure on Q9NPH5-4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
HW061173 - JP 2012529430-A/48: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. HW061174 - JP 2012529430-A/49: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. JA482133 - Sequence 116 from Patent WO2011072091. JA482134 - Sequence 117 from Patent WO2011072091. JB251981 - Sequence 48 from Patent EP2440214. JB251982 - Sequence 49 from Patent EP2440214. JE980425 - Sequence 116 from Patent EP2862929. JE980426 - Sequence 117 from Patent EP2862929. LP764880 - Sequence 48 from Patent EP3276004. LP764881 - Sequence 49 from Patent EP3276004. HW061175 - JP 2012529430-A/50: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. JA482135 - Sequence 118 from Patent WO2011072091. JB251983 - Sequence 50 from Patent EP2440214. JE980427 - Sequence 118 from Patent EP2862929. LP764882 - Sequence 50 from Patent EP3276004. AK291830 - Homo sapiens cDNA FLJ77156 complete cds, highly similar to Homo sapiens NADPH oxidase 4 variant (NOX4) mRNA. BC034780 - Homo sapiens mRNA similar to NADPH oxidase 4 (cDNA clone IMAGE:5179443). AB041035 - Homo sapiens Kox-1 mRNA for kidney superoxide-producing NADPH oxidase, complete cds. AF254621 - Homo sapiens NADPH oxidase 4 mRNA, complete cds. AK298323 - Homo sapiens cDNA FLJ56218 complete cds, highly similar to NADPH oxidase 4 (EC 1.6.3.-). AK057189 - Homo sapiens cDNA FLJ32627 fis, clone SYNOV1000049, highly similar to NADPH oxidase 4 (EC 1.6.3.-). AK298376 - Homo sapiens cDNA FLJ51029 complete cds, highly similar to NADPH oxidase 4 (EC 1.6.3.-). BC040105 - Homo sapiens NADPH oxidase 4, mRNA (cDNA clone MGC:48663 IMAGE:5590269), complete cds. AK298357 - Homo sapiens cDNA FLJ51027 complete cds, highly similar to NADPH oxidase 4 (EC 1.6.3.-). AK298328 - Homo sapiens cDNA FLJ51025 complete cds, highly similar to NADPH oxidase 4 (EC 1.6.3.-). AF261943 - Homo sapiens renal NAD(P)H-oxidase renox mRNA, complete cds. AJ704725 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant A. AJ704726 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant B. AJ704727 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant C. AJ704728 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant D. AJ704729 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant E. AY288918 - Homo sapiens NADPH oxidase 4 variant (NOX4) mRNA, complete cds. JF432404 - Synthetic construct Homo sapiens clone IMAGE:100073606 NADPH oxidase 4 (NOX4) gene, encodes complete protein. KJ893751 - Synthetic construct Homo sapiens clone ccsbBroadEn_03145 NOX4 gene, encodes complete protein. JD112087 - Sequence 93111 from Patent EP1572962. JD246993 - Sequence 228017 from Patent EP1572962. JD246994 - Sequence 228018 from Patent EP1572962. JD413430 - Sequence 394454 from Patent EP1572962. JD198127 - Sequence 179151 from Patent EP1572962. JD212734 - Sequence 193758 from Patent EP1572962. JD542757 - Sequence 523781 from Patent EP1572962. JD354356 - Sequence 335380 from Patent EP1572962. JD246992 - Sequence 228016 from Patent EP1572962. JD537804 - Sequence 518828 from Patent EP1572962. JD246990 - Sequence 228014 from Patent EP1572962. JD178262 - Sequence 159286 from Patent EP1572962. JD126562 - Sequence 107586 from Patent EP1572962. JD061993 - Sequence 43017 from Patent EP1572962. JD357460 - Sequence 338484 from Patent EP1572962. JD090359 - Sequence 71383 from Patent EP1572962. JD141339 - Sequence 122363 from Patent EP1572962. JD180813 - Sequence 161837 from Patent EP1572962. JD066520 - Sequence 47544 from Patent EP1572962. JD449051 - Sequence 430075 from Patent EP1572962. AK311389 - Homo sapiens cDNA, FLJ18431. CU691812 - Synthetic construct Homo sapiens gateway clone IMAGE:100021174 5' read NOX4 mRNA. BC051371 - Homo sapiens NADPH oxidase 4, mRNA (cDNA clone IMAGE:6580820), complete cds. JD164701 - Sequence 145725 from Patent EP1572962. JD126043 - Sequence 107067 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: AJ704728, Q9NPH5-4, RENOX UCSC ID: uc001pcw.3 RefSeq Accession: NR_026571
Protein: , splice isoform of Q9NPH5-4 Q9NPH5
Gene Model Information
9 CDS single in 3' UTR:
816 CDS single in intron:
Alignment % ID:
1832.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.