Human Gene TRIM49 (ENST00000329758.5) Description and Page Index
  Description: Homo sapiens tripartite motif containing 49 (TRIM49), mRNA. (from RefSeq NM_020358)
RefSeq Summary (NM_020358): The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010].
Gencode Transcript: ENST00000329758.5
Gencode Gene: ENSG00000168930.13
Transcript (Including UTRs)
   Position: hg38 chr11:89,797,655-89,808,575 Size: 10,921 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr11:89,798,130-89,804,469 Size: 6,340 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:89,797,655-89,808,575)mRNA (may differ from genome)Protein (452 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: TRI49_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 49; AltName: Full=RING finger protein 18; AltName: Full=Testis-specific RING-finger protein;
TISSUE SPECIFICITY: Preferentially expressed in testis.
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.09 RPKM in Testis
Total median expression: 0.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.10329-0.247 Picture PostScript Text
3' UTR -95.30475-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00622 - SPRY domain
PF00643 - B-box zinc finger

ModBase Predicted Comparative 3D Structure on P0CI25
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  AB037682 - Homo sapiens mRNA for testis-specific RING Finger protein, complete cds.
JD300424 - Sequence 281448 from Patent EP1572962.
JD305701 - Sequence 286725 from Patent EP1572962.
JD350870 - Sequence 331894 from Patent EP1572962.
JD089973 - Sequence 70997 from Patent EP1572962.
JD058127 - Sequence 39151 from Patent EP1572962.
JD469721 - Sequence 450745 from Patent EP1572962.
BC126472 - Homo sapiens tripartite motif-containing 49, mRNA (cDNA clone MGC:161750 IMAGE:8992188), complete cds.
BC075019 - Homo sapiens tripartite motif-containing 49, mRNA (cDNA clone MGC:104001 IMAGE:30915409), complete cds.
BC075020 - Homo sapiens tripartite motif-containing 49, mRNA (cDNA clone MGC:104159 IMAGE:30915620), complete cds.
EU446828 - Synthetic construct Homo sapiens clone IMAGE:100069966; IMAGE:100012037; FLH257107.01L tripartite motif-containing 49 (TRIM49) gene, encodes complete protein.
HQ258122 - Synthetic construct Homo sapiens clone IMAGE:100072551 tripartite motif-containing 49 (TRIM49) gene, encodes complete protein.
KJ894385 - Synthetic construct Homo sapiens clone ccsbBroadEn_03779 TRIM49 gene, encodes complete protein.
JD099557 - Sequence 80581 from Patent EP1572962.
JF968461 - Homo sapiens clone F1 TRIM49 mRNA, partial cds.
JF968462 - Homo sapiens clone F2 TRIM49L2 mRNA, partial cds.
JD440573 - Sequence 421597 from Patent EP1572962.
JD440574 - Sequence 421598 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVR7, A0AVR9, NM_020358, P0CI25, Q6DJV1, Q9NS80, RNF18, TRI49_HUMAN, uc001pdb.1, uc001pdb.2, uc001pdb.3
UCSC ID: uc001pdb.3
RefSeq Accession: NM_020358
Protein: P0CI25 (aka TRI49_HUMAN)
CCDS: CCDS8287.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.