Human Gene TRIM49 (ENST00000329758.5) Description and Page Index
  Description: Homo sapiens tripartite motif containing 49 (TRIM49), mRNA. (from RefSeq NM_020358)
RefSeq Summary (NM_020358): The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010].
Gencode Transcript: ENST00000329758.5
Gencode Gene: ENSG00000168930.13
Transcript (Including UTRs)
   Position: hg38 chr11:89,797,655-89,808,575 Size: 10,921 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr11:89,798,130-89,804,469 Size: 6,340 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:89,797,655-89,808,575)mRNA (may differ from genome)Protein (452 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 49; AltName: Full=RING finger protein 18; AltName: Full=Testis-specific RING-finger protein;
TISSUE SPECIFICITY: Preferentially expressed in testis.
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 1 B box-type zinc finger.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.09 RPKM in Testis
Total median expression: 0.09 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.10329-0.247 Picture PostScript Text
3' UTR -95.30475-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING

Pfam Domains:
PF00622 - SPRY domain
PF00643 - B-box zinc finger

ModBase Predicted Comparative 3D Structure on P0CI25
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding

Cellular Component:
GO:0005622 intracellular

-  Descriptions from all associated GenBank mRNAs
  AB037682 - Homo sapiens mRNA for testis-specific RING Finger protein, complete cds.
JD300424 - Sequence 281448 from Patent EP1572962.
JD305701 - Sequence 286725 from Patent EP1572962.
JD350870 - Sequence 331894 from Patent EP1572962.
JD089973 - Sequence 70997 from Patent EP1572962.
JD058127 - Sequence 39151 from Patent EP1572962.
JD469721 - Sequence 450745 from Patent EP1572962.
BC126472 - Homo sapiens tripartite motif-containing 49, mRNA (cDNA clone MGC:161750 IMAGE:8992188), complete cds.
BC075019 - Homo sapiens tripartite motif-containing 49, mRNA (cDNA clone MGC:104001 IMAGE:30915409), complete cds.
BC075020 - Homo sapiens tripartite motif-containing 49, mRNA (cDNA clone MGC:104159 IMAGE:30915620), complete cds.
EU446828 - Synthetic construct Homo sapiens clone IMAGE:100069966; IMAGE:100012037; FLH257107.01L tripartite motif-containing 49 (TRIM49) gene, encodes complete protein.
HQ258122 - Synthetic construct Homo sapiens clone IMAGE:100072551 tripartite motif-containing 49 (TRIM49) gene, encodes complete protein.
KJ894385 - Synthetic construct Homo sapiens clone ccsbBroadEn_03779 TRIM49 gene, encodes complete protein.
JD099557 - Sequence 80581 from Patent EP1572962.
JF968461 - Homo sapiens clone F1 TRIM49 mRNA, partial cds.
JF968462 - Homo sapiens clone F2 TRIM49L2 mRNA, partial cds.
JD440573 - Sequence 421597 from Patent EP1572962.
JD440574 - Sequence 421598 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVR7, A0AVR9, NM_020358, P0CI25, Q6DJV1, Q9NS80, RNF18, TRI49_HUMAN, uc001pdb.1, uc001pdb.2, uc001pdb.3
UCSC ID: uc001pdb.3
RefSeq Accession: NM_020358
Protein: P0CI25 (aka TRI49_HUMAN)
CCDS: CCDS8287.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.