Human Gene AMOTL1 (ENST00000317829.12) from GENCODE V44
Description: Homo sapiens angiomotin like 1 (AMOTL1), transcript variant 2, mRNA. (from RefSeq NM_001301007) RefSeq Summary (NM_001301007): The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000317829.12 Gencode Gene: ENSG00000166025.18 Transcript (Including UTRs) Position: hg38 chr11:94,768,342-94,876,748 Size: 108,407 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr11:94,768,512-94,870,795 Size: 102,284 Coding Exon Count: 12
ID:AMOL1_HUMAN DESCRIPTION: RecName: Full=Angiomotin-like protein 1; FUNCTION: Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. SUBCELLULAR LOCATION: Cell junction, tight junction (By similarity). PTM: Polyubiquitinated by NEDD4, leading to proteasomal degradation. SIMILARITY: Belongs to the angiomotin family. SEQUENCE CAUTION: Sequence=BAB84910.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB84910.1; Type=Frameshift; Positions=592, 944;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IY63
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.