Human Gene FAM76B (ENST00000358780.10) from GENCODE V44
  Description: Homo sapiens family with sequence similarity 76 member B (FAM76B), transcript variant 1, mRNA. (from RefSeq NM_144664)
Gencode Transcript: ENST00000358780.10
Gencode Gene: ENSG00000077458.13
Transcript (Including UTRs)
   Position: hg38 chr11:95,768,953-95,789,782 Size: 20,830 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr11:95,771,561-95,789,478 Size: 17,918 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:95,768,953-95,789,782)mRNA (may differ from genome)Protein (339 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FA76B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM76B;
SUBCELLULAR LOCATION: Nucleus speckle.
DOMAIN: The polyhistidine repeat acts as a targeting signal to nuclear speckles (PubMed:19266028).
PTM: Isoform 2 is ubiquitinated at Lys-225.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the FAM76 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.21 RPKM in Testis
Total median expression: 256.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -168.40304-0.554 Picture PostScript Text
3' UTR -538.802608-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q5HYJ3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI Ensembl   
Protein Sequence Protein Sequence   
Alignment Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  BC028727 - Homo sapiens family with sequence similarity 76, member B, mRNA (cDNA clone MGC:33342 IMAGE:4824833), complete cds.
BX647586 - Homo sapiens mRNA; cDNA DKFZp313F092 (from clone DKFZp313F092).
BC026013 - Homo sapiens family with sequence similarity 76, member B, mRNA (cDNA clone MGC:33371 IMAGE:5270248), complete cds.
JD019096 - Sequence 120 from Patent EP1572962.
AM392906 - Synthetic construct Homo sapiens clone IMAGE:100002488 for hypothetical protein (FAM76B gene).
JD307680 - Sequence 288704 from Patent EP1572962.
JD529856 - Sequence 510880 from Patent EP1572962.
JD382224 - Sequence 363248 from Patent EP1572962.
JD442082 - Sequence 423106 from Patent EP1572962.
AK021591 - Homo sapiens cDNA FLJ11529 fis, clone HEMBA1002629.
JD237131 - Sequence 218155 from Patent EP1572962.
JD492350 - Sequence 473374 from Patent EP1572962.
JD182213 - Sequence 163237 from Patent EP1572962.
CU693100 - Synthetic construct Homo sapiens gateway clone IMAGE:100016837 5' read FAM76B mRNA.
KJ903823 - Synthetic construct Homo sapiens clone ccsbBroadEn_13217 FAM76B gene, encodes complete protein.
DQ891214 - Synthetic construct clone IMAGE:100003844; FLH170216.01X; RZPDo839C1298D family with sequence similarity 76, member B (FAM76B) gene, encodes complete protein.
DQ894397 - Synthetic construct Homo sapiens clone IMAGE:100008857; FLH170212.01L; RZPDo839C1297D family with sequence similarity 76, member B (FAM76B) gene, encodes complete protein.
AK313727 - Homo sapiens cDNA, FLJ94326.
JD340043 - Sequence 321067 from Patent EP1572962.
JD195741 - Sequence 176765 from Patent EP1572962.
JD179182 - Sequence 160206 from Patent EP1572962.
JD407209 - Sequence 388233 from Patent EP1572962.
JD257517 - Sequence 238541 from Patent EP1572962.
JD469337 - Sequence 450361 from Patent EP1572962.
JD141333 - Sequence 122357 from Patent EP1572962.
JD469336 - Sequence 450360 from Patent EP1572962.
JD426644 - Sequence 407668 from Patent EP1572962.
JD095131 - Sequence 76155 from Patent EP1572962.
JD142348 - Sequence 123372 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000358780.1, ENST00000358780.2, ENST00000358780.3, ENST00000358780.4, ENST00000358780.5, ENST00000358780.6, ENST00000358780.7, ENST00000358780.8, ENST00000358780.9, FA76B_HUMAN, NM_144664, Q5HYJ3, Q6PIU3, Q8TC53, uc001pfn.1, uc001pfn.2, uc001pfn.3, uc001pfn.4
UCSC ID: ENST00000358780.10
RefSeq Accession: NM_144664
Protein: Q5HYJ3 (aka FA76B_HUMAN)
CCDS: CCDS41700.1, CCDS81619.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.