Human Gene KBTBD3 (ENST00000531837.2) from GENCODE V44
Description: Homo sapiens kelch repeat and BTB domain containing 3 (KBTBD3), transcript variant 2, mRNA. (from RefSeq NM_198439)
Gencode Transcript: ENST00000531837.2
Gencode Gene: ENSG00000182359.15
Transcript (Including UTRs)
Position: hg38 chr11:106,051,098-106,077,347 Size: 26,250 Total Exon Count: 4 Strand: -
Coding Region
Position: hg38 chr11:106,052,850-106,059,097 Size: 6,248 Coding Exon Count: 2
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: KBTB3_HUMAN
DESCRIPTION: RecName: Full=Kelch repeat and BTB domain-containing protein 3; AltName: Full=BTB and kelch domain-containing protein 3;
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.SIMILARITY: Contains 1 BTB (POZ) domain.SIMILARITY: Contains 5 Kelch repeats.SEQUENCE CAUTION: Sequence=AAI17467.1; Type=Erroneous initiation; Sequence=CAE45804.1; Type=Erroneous initiation; Sequence=EAW67073.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR017096 - Kelch-like_gigaxonin
IPR015915 - Kelch-typ_b-propeller
IPR006652 - Kelch_1
Pfam Domains: PF07707 - BTB And C-terminal Kelch
PF00651 - BTB/POZ domain
PF01344 - Kelch motif
ModBase Predicted Comparative 3D Structure on Q8NAB2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity
Biological Process: GO:0016567 protein ubiquitination
Cellular Component: GO:0031463 Cul3-RING ubiquitin ligase complex
Descriptions from all associated GenBank mRNAs
BX647830 - Homo sapiens mRNA; cDNA DKFZp779E1617 (from clone DKFZp779E1617).BX640672 - Homo sapiens mRNA; cDNA DKFZp686D14128 (from clone DKFZp686D14128).LF384507 - JP 2014500723-A/192010: Polycomb-Associated Non-Coding RNAs.MA620084 - JP 2018138019-A/192010: Polycomb-Associated Non-Coding RNAs.AK055247 - Homo sapiens cDNA FLJ30685 fis, clone FCBBF2000276.JD496814 - Sequence 477838 from Patent EP1572962.JD237222 - Sequence 218246 from Patent EP1572962.BC117466 - Homo sapiens kelch repeat and BTB (POZ) domain containing 3, mRNA (cDNA clone MGC:151075 IMAGE:40126017), complete cds.AK092993 - Homo sapiens cDNA FLJ35674 fis, clone SPLEN2018299.AX747842 - Sequence 1367 from Patent EP1308459.JD449908 - Sequence 430932 from Patent EP1572962.JD551742 - Sequence 532766 from Patent EP1572962.AK289915 - Homo sapiens cDNA FLJ76341 complete cds, highly similar to Homo sapiens kelch repeat and BTB (POZ) domain containing 3 (KBTBD3), transcript variant 1, mRNA.JD553457 - Sequence 534481 from Patent EP1572962.KJ895571 - Synthetic construct Homo sapiens clone ccsbBroadEn_04965 KBTBD3 gene, encodes complete protein.EU831921 - Synthetic construct Homo sapiens clone HAIB:100066950; DKFZo008B0923 kelch repeat and BTB (POZ) domain containing 3 protein (KBTBD3) gene, encodes complete protein.GQ891308 - Homo sapiens clone HEL-S-31a epididymis secretory sperm binding protein mRNA, complete cds.EU832015 - Synthetic construct Homo sapiens clone HAIB:100067044; DKFZo004B0924 kelch repeat and BTB (POZ) domain containing 3 protein (KBTBD3) gene, encodes complete protein.HQ258322 - Synthetic construct Homo sapiens clone IMAGE:100072631 kelch repeat and BTB (POZ) domain containing 3 (KBTBD3), transcript variant 2 (KBTBD3) gene, encodes complete protein.LF375532 - JP 2014500723-A/183035: Polycomb-Associated Non-Coding RNAs.MA611109 - JP 2018138019-A/183035: Polycomb-Associated Non-Coding RNAs.BC047311 - Homo sapiens kelch repeat and BTB (POZ) domain containing 3, mRNA (cDNA clone IMAGE:5178766), partial cds.BC107691 - Homo sapiens kelch repeat and BTB (POZ) domain containing 3, mRNA (cDNA clone IMAGE:4287155), partial cds.BC062667 - Homo sapiens kelch repeat and BTB (POZ) domain containing 3, mRNA (cDNA clone IMAGE:6592764).LF375531 - JP 2014500723-A/183034: Polycomb-Associated Non-Coding RNAs.MA611108 - JP 2018138019-A/183034: Polycomb-Associated Non-Coding RNAs.AK124540 - Homo sapiens cDNA FLJ42549 fis, clone BRACE3004998.LF375529 - JP 2014500723-A/183032: Polycomb-Associated Non-Coding RNAs.MA611106 - JP 2018138019-A/183032: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: BKLHD3, ENST00000531837.1, KBTB3_HUMAN, NM_198439, Q6N066, Q86X38, Q8NAB2, Q96NK5, uc001pja.1, uc001pja.2, uc001pja.3, uc001pja.4, uc001pja.5UCSC ID: ENST00000531837.2RefSeq Accession: NM_198439
Protein: Q8NAB2
(aka KBTB3_HUMAN or KBT3_HUMAN)
CCDS: CCDS8334.1
Methods, Credits, and Use Restrictions
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