Human Gene OPCML (uc001qgu.3) Description and Page Index
  Description: Homo sapiens opioid binding protein/cell adhesion molecule-like (OPCML), transcript variant 2, mRNA.
RefSeq Summary (NM_001012393): This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
Transcript (Including UTRs)
   Position: hg19 chr11:132,284,875-133,402,403 Size: 1,117,529 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr11:132,290,087-133,402,219 Size: 1,112,133 Coding Exon Count: 8 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:132,284,875-133,402,403)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): OPCML
CDC HuGE Published Literature: OPCML
Positive Disease Associations: Angiography , Blood Pressure , Blood Proteins , Body Mass Index , Calcium , Cardiovascular Diseases , Cholesterol , Cholesterol, LDL , Creatinine , Diabetes Mellitus , Exercise Test , Heart Rate , Menopause , Respiratory Function Tests , Schizophrenia , Sleep , Tunica Media , Waist-Hip Ratio
Related Studies:
  1. Angiography
    Ramachandran S Vasan et al. BMC medical genetics 2007, Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study., BMC medical genetics. [PubMed 17903301]
    In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community.
  2. Blood Pressure
    Daniel Levy et al. BMC medical genetics 2007, Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness., BMC medical genetics. [PubMed 17903302]
    These results of genome-wide association testing for blood pressure and arterial stiffness phenotypes in an unselected community-based sample of adults may aid in the identification of the genetic basis of hypertension and arterial disease, help identify high risk individuals, and guide novel therapies for hypertension. Additional studies are needed to replicate any associations identified in these analyses.
  3. Blood Pressure
    Daniel Levy et al. BMC medical genetics 2007, Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness., BMC medical genetics. [PubMed 17903302]
    These results of genome-wide association testing for blood pressure and arterial stiffness phenotypes in an unselected community-based sample of adults may aid in the identification of the genetic basis of hypertension and arterial disease, help identify high risk individuals, and guide novel therapies for hypertension. Additional studies are needed to replicate any associations identified in these analyses.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: OPCML
Diseases sorted by gene-association score: ovarian cancer, somatic* (1266), juvenile pilocytic astrocytoma (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.25 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 145.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.10184-0.327 Picture PostScript Text
3' UTR -1516.275212-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00047 - Immunoglobulin domain
PF07679 - Immunoglobulin I-set domain
PF07686 - Immunoglobulin V-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q14982-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BX537377 - Homo sapiens mRNA; cDNA DKFZp686H1949 (from clone DKFZp686H1949); complete cds.
AK315859 - Homo sapiens cDNA, FLJ79508 complete cds, highly similar to Opioid-binding protein/cell adhesion moleculeprecursor.
AB529104 - Synthetic construct DNA, clone: pF1KB4518, Homo sapiens OPCML gene for opioid binding protein/cell adhesion molecule-like, without stop codon, in Flexi system.
BC117254 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:150863 IMAGE:40125805), complete cds.
BC126251 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:161529 IMAGE:8991967), complete cds.
BC143945 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:177480 IMAGE:9052463), complete cds.
BC143946 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:177481 IMAGE:9052464), complete cds.
AK299908 - Homo sapiens cDNA FLJ52276 complete cds, highly similar to Opioid-binding protein/cell adhesion molecule precursor.
L34774 - Human (clone pHOM) opioid-binding cell adhesion molecule mRNA, complete cds.
AK316273 - Homo sapiens cDNA, FLJ79172 complete cds, highly similar to Opioid-binding protein/cell adhesion moleculeprecursor.
AK299528 - Homo sapiens cDNA FLJ51061 complete cds, highly similar to Opioid-binding protein/cell adhesion molecule precursor.
AK289695 - Homo sapiens cDNA FLJ76211 complete cds, highly similar to Homo sapiens opioid binding protein/cell adhesion molecule-like(OPCML), mRNA.
AK316491 - Homo sapiens cDNA, FLJ79390 complete cds, highly similar to Opioid-binding protein/cell adhesion molecule precursor.
BC074742 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:104014 IMAGE:30915458), complete cds.
BC074773 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:103819 IMAGE:30915200), complete cds.
EU562300 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 6 mRNA sequence, alternatively spliced.
EU562298 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 4 mRNA sequence, alternatively spliced.
EU562299 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 5 mRNA sequence, alternatively spliced.
EU562296 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 2 mRNA sequence, alternatively spliced.
AK314077 - Homo sapiens cDNA, FLJ94748.
EU562295 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 1 mRNA sequence, alternatively spliced.
EU562297 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 3 mRNA sequence, alternatively spliced.
HQ258388 - Synthetic construct Homo sapiens clone IMAGE:100072817 Unknown protein gene, encodes complete protein.
KJ897278 - Synthetic construct Homo sapiens clone ccsbBroadEn_06672 OPCML gene, encodes complete protein.
KJ901615 - Synthetic construct Homo sapiens clone ccsbBroadEn_11009 OPCML gene, encodes complete protein.
AF070577 - Homo sapiens clone 24461 mRNA sequence.
AK125185 - Homo sapiens cDNA FLJ43195 fis, clone FEBRA2002456.
U79251 - Human clone 23878 mRNA sequence.
JD155126 - Sequence 136150 from Patent EP1572962.
JD339304 - Sequence 320328 from Patent EP1572962.
JD189584 - Sequence 170608 from Patent EP1572962.
JD080758 - Sequence 61782 from Patent EP1572962.
JD287908 - Sequence 268932 from Patent EP1572962.
JD073592 - Sequence 54616 from Patent EP1572962.
JD412288 - Sequence 393312 from Patent EP1572962.
JD190356 - Sequence 171380 from Patent EP1572962.
JD298032 - Sequence 279056 from Patent EP1572962.
JD067936 - Sequence 48960 from Patent EP1572962.
JD313467 - Sequence 294491 from Patent EP1572962.
JD303088 - Sequence 284112 from Patent EP1572962.
JD320211 - Sequence 301235 from Patent EP1572962.
JD039199 - Sequence 20223 from Patent EP1572962.
JD465093 - Sequence 446117 from Patent EP1572962.
JD349507 - Sequence 330531 from Patent EP1572962.
JD378873 - Sequence 359897 from Patent EP1572962.
JD113402 - Sequence 94426 from Patent EP1572962.
JD273544 - Sequence 254568 from Patent EP1572962.
JD163817 - Sequence 144841 from Patent EP1572962.
JD055970 - Sequence 36994 from Patent EP1572962.
JD399993 - Sequence 381017 from Patent EP1572962.
JD347222 - Sequence 328246 from Patent EP1572962.
JD518272 - Sequence 499296 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14982 (Reactome details) participates in the following event(s):

R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: IGLON1, NM_001012393, NP_001012393, OBCAM, Q14982-2
UCSC ID: uc001qgu.3
RefSeq Accession: NM_001012393
Protein: Q14982-2, splice isoform of Q14982 CCDS: CCDS31722.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001012393.1
exon count: 8CDS single in 3' UTR: no RNA size: 6413
ORF size: 1017CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2234.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.