Human Gene NRIP2 (ENST00000337508.9) from GENCODE V44
  Description: Homo sapiens nuclear receptor interacting protein 2 (NRIP2), mRNA. (from RefSeq NM_031474)
Gencode Transcript: ENST00000337508.9
Gencode Gene: ENSG00000053702.15
Transcript (Including UTRs)
   Position: hg38 chr12:2,825,348-2,835,035 Size: 9,688 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr12:2,827,207-2,834,983 Size: 7,777 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:2,825,348-2,835,035)mRNA (may differ from genome)Protein (281 aa)
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-  Comments and Description Text from UniProtKB
  ID: NRIP2_HUMAN
DESCRIPTION: RecName: Full=Nuclear receptor-interacting protein 2;
FUNCTION: Down-regulates transcriptional activation by nuclear receptors such as NR1F2 (By similarity).
SUBUNIT: Interacts with NR1F2, RARA and THRB in a ligand-dependent manner (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.04 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 302.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.8052-0.169 Picture PostScript Text
3' UTR -611.801859-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021109 - Peptidase_aspartic
IPR019103 - Peptidase_aspartic_euk-pred

Pfam Domains:
PF09668 - Aspartyl protease

ModBase Predicted Comparative 3D Structure on Q9BQI9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006508 proteolysis

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC036063 - Homo sapiens nuclear receptor interacting protein 2, mRNA (cDNA clone MGC:33681 IMAGE:5276999), complete cds.
AL136557 - Homo sapiens mRNA; cDNA DKFZp761G1913 (from clone DKFZp761G1913).
AK054740 - Homo sapiens cDNA FLJ30178 fis, clone BRACE2001070.
AK098063 - Homo sapiens cDNA FLJ40744 fis, clone TRACH2000045, highly similar to Homo sapiens nuclear receptor interacting protein 2 (NRIP2), mRNA.
JD556125 - Sequence 537149 from Patent EP1572962.
JD537685 - Sequence 518709 from Patent EP1572962.
JD135292 - Sequence 116316 from Patent EP1572962.
JD101744 - Sequence 82768 from Patent EP1572962.
JD202096 - Sequence 183120 from Patent EP1572962.
JD282055 - Sequence 263079 from Patent EP1572962.
JD202947 - Sequence 183971 from Patent EP1572962.
JD073455 - Sequence 54479 from Patent EP1572962.
JD416121 - Sequence 397145 from Patent EP1572962.
JD167030 - Sequence 148054 from Patent EP1572962.
JD392797 - Sequence 373821 from Patent EP1572962.
JD536737 - Sequence 517761 from Patent EP1572962.
JD338770 - Sequence 319794 from Patent EP1572962.
JD414617 - Sequence 395641 from Patent EP1572962.
JD193909 - Sequence 174933 from Patent EP1572962.
JD531313 - Sequence 512337 from Patent EP1572962.
JD061865 - Sequence 42889 from Patent EP1572962.
JD494520 - Sequence 475544 from Patent EP1572962.
JD517800 - Sequence 498824 from Patent EP1572962.
JD174130 - Sequence 155154 from Patent EP1572962.
JD351890 - Sequence 332914 from Patent EP1572962.
JD517799 - Sequence 498823 from Patent EP1572962.
JD144044 - Sequence 125068 from Patent EP1572962.
JD257700 - Sequence 238724 from Patent EP1572962.
JD289401 - Sequence 270425 from Patent EP1572962.
JD500609 - Sequence 481633 from Patent EP1572962.
JD348304 - Sequence 329328 from Patent EP1572962.
JD312665 - Sequence 293689 from Patent EP1572962.
JD219103 - Sequence 200127 from Patent EP1572962.
JD529651 - Sequence 510675 from Patent EP1572962.
JD430442 - Sequence 411466 from Patent EP1572962.
JD401522 - Sequence 382546 from Patent EP1572962.
JD170451 - Sequence 151475 from Patent EP1572962.
JD047712 - Sequence 28736 from Patent EP1572962.
JD238411 - Sequence 219435 from Patent EP1572962.
JD168687 - Sequence 149711 from Patent EP1572962.
JD528956 - Sequence 509980 from Patent EP1572962.
JD243954 - Sequence 224978 from Patent EP1572962.
JD384507 - Sequence 365531 from Patent EP1572962.
JD226349 - Sequence 207373 from Patent EP1572962.
JD219216 - Sequence 200240 from Patent EP1572962.
JD544705 - Sequence 525729 from Patent EP1572962.
JD106007 - Sequence 87031 from Patent EP1572962.
JD426469 - Sequence 407493 from Patent EP1572962.
JD564470 - Sequence 545494 from Patent EP1572962.
JD341063 - Sequence 322087 from Patent EP1572962.
JD378616 - Sequence 359640 from Patent EP1572962.
JD480601 - Sequence 461625 from Patent EP1572962.
JD276599 - Sequence 257623 from Patent EP1572962.
JD268570 - Sequence 249594 from Patent EP1572962.
JD447356 - Sequence 428380 from Patent EP1572962.
JD266616 - Sequence 247640 from Patent EP1572962.
JD256180 - Sequence 237204 from Patent EP1572962.
JD151279 - Sequence 132303 from Patent EP1572962.
JD464836 - Sequence 445860 from Patent EP1572962.
JD409946 - Sequence 390970 from Patent EP1572962.
JD109452 - Sequence 90476 from Patent EP1572962.
AK300944 - Homo sapiens cDNA FLJ54174 complete cds, highly similar to Homo sapiens nuclear receptor interacting protein 2 (NRIP2), mRNA.
JD080505 - Sequence 61529 from Patent EP1572962.
JD152070 - Sequence 133094 from Patent EP1572962.
JD223602 - Sequence 204626 from Patent EP1572962.
JD203383 - Sequence 184407 from Patent EP1572962.
JD228713 - Sequence 209737 from Patent EP1572962.
JD307871 - Sequence 288895 from Patent EP1572962.
JD314075 - Sequence 295099 from Patent EP1572962.
JD113492 - Sequence 94516 from Patent EP1572962.
BC131562 - Homo sapiens nuclear receptor interacting protein 2, mRNA (cDNA clone MGC:148142 IMAGE:40109200), complete cds.
JD163268 - Sequence 144292 from Patent EP1572962.
JD387078 - Sequence 368102 from Patent EP1572962.
JD239408 - Sequence 220432 from Patent EP1572962.
KJ894897 - Synthetic construct Homo sapiens clone ccsbBroadEn_04291 NRIP2 gene, encodes complete protein.
AB528149 - Synthetic construct DNA, clone: pF1KE0106, Homo sapiens NRIP2 gene for nuclear receptor interacting protein 2, without stop codon, in Flexi system.
AM393084 - Synthetic construct Homo sapiens clone IMAGE:100001671 for hypothetical protein (NRIP2 gene).

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000337508.1, ENST00000337508.2, ENST00000337508.3, ENST00000337508.4, ENST00000337508.5, ENST00000337508.6, ENST00000337508.7, ENST00000337508.8, NM_031474, NRIP2_HUMAN, Q9BQI9, uc001qlc.1, uc001qlc.2, uc001qlc.3, uc001qlc.4, uc001qlc.5
UCSC ID: ENST00000337508.9
RefSeq Accession: NM_031474
Protein: Q9BQI9 (aka NRIP2_HUMAN)
CCDS: CCDS8514.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.