Human Gene SOX5 (ENST00000451604.7) from GENCODE V44
Description: Homo sapiens SRY-box transcription factor 5 (SOX5), transcript variant 1, mRNA. (from RefSeq NM_006940) RefSeq Summary (NM_006940): This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000451604.7 Gencode Gene: ENSG00000134532.20 Transcript (Including UTRs) Position: hg38 chr12:23,529,504-23,949,670 Size: 420,167 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chr12:23,534,219-23,949,601 Size: 415,383 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35711
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0032332 positive regulation of chondrocyte differentiation GO:0055059 asymmetric neuroblast division GO:0061036 positive regulation of cartilage development GO:0071560 cellular response to transforming growth factor beta stimulus GO:2000741 positive regulation of mesenchymal stem cell differentiation
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